Attitudes to Genetic Engineering

Japanese and International Comparisons

Darryl R. J. Macer, Ph.D. Eubios Ethics Institute 1992


Copyright 1992, Darryl R. J. Macer. All commercial rights reserved. This publication may be reproduced for limited educational or academic use, however please enquire with the author.

4. Genetic Manipulation


page 39-81 in Attitudes to Genetic Engineering: Japanese and International Comparisons D.R.J. Macer (Eubios Ethics Institute, 1992).


4.1. Knowledge of Genetic Manipulation

More specific questions than those asked in Q5, were used in Q7. Rather than testing concerns about the techniques included by the broad term "genetic engineering", the views of genetic manipulation on four types of organisms were examined: humans, animals, plants and microbes. The questions used by Couchman & Fink-Jensen (1990) were used, with room for free response to list reasons for acceptance, benefits and risks perceived. The questions were:

Q7. Can you tell me how much you have heard or read about...?
Manipulating genetic material in human cells
Manipulating genetic material in microbes
Manipulating genetic material in plants
Manipulating genetic material in animals
Use this scale...
1 I have not heard of this
2 I have heard the words but no more
3 I have heard the words and have some understanding of the idea behind it

Please answer the questions below:
Q7b. Which, if any, of those biological methods you've heard of are acceptable to you for any reason?
1 Acceptable
2 Unacceptable (If unacceptable write why each one is not acceptable to you)

Q7c. Which of those biological methods, if any, of those you've heard of could provide benefits for Japan?
1 No benefit
2 Benefit (If a benefit, what benefits do you believe each one could produce?)

Q7d. Which, if any, of those biological methods could present serious risks or hazards in Japan?
1 Risk
2 No risk (If a risk, what serious risks or hazards do you believe each one could present in Japan?)

Improving Awareness of Genetic Manipulation

Q7a asked about the awareness of techniques of genetic manipulation, in human cells, microbes, plants and animals. The results are summarised in Table 4-1. The most familiar was genetic manipulation of plants, with 45% of the public saying that they could understand this, and only 8% saying that they had not heard of it. Surprisingly, the least familiar was genetic manipulation of microbes, despite the decade of use of microbes for production of recombinant DNA products, though still 33% said that they understood this, while 21% said that they had not heard of it. The awareness of genetic manipulation (Q7a) was correlated with the interest in science (Q1) and the awareness of genetic engineering (Q5a).

These levels of awareness are higher than past surveys in Japan, suggesting that public understanding of genetic manipulation is improving. This was discussed in chapter 3, for the general words "biotechnology" and "genetic engineering". Less than 8% of the public respondents had not heard of any type of genetic manipulation, which represents a very high level of awareness, especially if we compare it to a figure of 25-30% in New Zealand (Couchman & Fink-Jensen 1990). The New Zealand value was obtained in interviews with a much higher response rate, possibly some of the Japanese non-respondents did not respond because they did not understand anything, so the real level of awareness may be somewhat lower.

The high school biology teachers were most familiar with genetic manipulation of microbes, which 83% said they could understand, with plant genetic manipulation being the next most familiar. Only 3.5% of teachers said that they had not heard of these techniques, but they had less familiarity with genetic manipulation of animals and humans. Scientists had a very similar level of familiarity with these techniques to the teachers, with the total academics having somewhat less familiarity. Students were intermediate in their familiarity. The responses by New Zealand teachers and scientists to Q7a indicate a higher level of unawareness of genetic engineering in humans and animals. Part of this difference could be related to the publicity associated with the increasing use of human gene therapy, in mid 1991 compared to mid 1990, however this may not explain all the differences.


Table 4-1 Awareness of genetic manipulation (%'s)

Values written in small figures are those obtained in New Zealand (Couchman & Fink-Jensen 1990). Note that New Zealand teachers and scientists were only asked whether they had heard, or not heard of, the subjects (Q7a).

Sample:
Public
Students
HighSchool Biology Teachers
Total

Academics
University of Tsukuba Staff
Total Scientists
Number533 202225 722246 550

Human cells
Not heard35 14.5 9.932 9.3 10.914.6 34 9.5
Heard40 49.2 41.668 29.8 31.145.5 66 25.8
Understand25 36.3 48.560.9 58.039.9 64.7

Plant cells
Not heard30 8.3 3.04 3.6 3.36.1 12 2.4
Heard44 46.5 32.296 18.7 25.544.3 88 20.0
Understand26 45.2 64.877.7 71.249.6 77.6

Microbes
Not heard59 21.2 14.84 3.5 6.813.5 19 3.3
Heard29 45.8 32.296 13.8 25.244.1 81 18.2
Understand12 33.0 54.082.7 68.042.4 78.5

Animals
Not heard31 8.1 5.012 5.4 5.17.4 16 4.0
Heard43 52.5 40.188 26.0 30.850.6 84 24.2
Understand26 39.4 54.968.6 64.142.0 71.8

4.2. Acceptability of Genetic Manipulation

To be aware of genetic manipulation is a different thing from accepting genetic manipulation, the same as is true of any scientific development. In the responses to Q7b we see clear differentiation by all groups of the acceptability of genetic manipulation depending on the organism, see Table 4-2. There is clear support for genetic manipulation of plants and microbes from all groups. There is less support for genetic manipulation of animals, but still a majority of all groups thinks that it is acceptable. However, the public thought that genetic manipulation of human cells (which will often be interpreted to mean human beings), is unacceptable. Other groups were more equally split on this question, though only scientists had a majority in favour of it.

In both Japan and New Zealand genetic manipulation of plants is the most acceptable type, see Figure 4-1. Followed by genetic manipulation of microbes, animals and humans, in order of decreasing acceptability. About half of the teacher and scientist samples think that human genetic manipulation (human cells) is acceptable, in both countries. This preference order is the same as that obtained in the USA in 1986 (OTA 1987), but their question asked interviewees to rank their acceptability on a ten point scale, 1-10, so we cannot compare the acceptability ranks. It is also very likely that the acceptability values have shifted since 1986 in the USA.

The reasons for unacceptability were asked, and these are presented in Table 4-3. They are perhaps the most interesting result. For different organisms they were different, as in New Zealand. The method used to analyse the reasoning was to assign the comments to categories. A total of 38 different categories were used in the computer data analysis. Although a variety of comments were written, generally they could easily be assigned to categories. To make this assessment more standard, all computer categorisation of comments was personally done within a short time period. For each distinct reason given in the comment, a count of 1 was scored in one of the categories of the data sheet in the computer. The most reasons given for a single comment was 3, but generally there were only 1 or 2 reasons. Also, a high proportion did not write any comment, as is shown in Table 4-3. More university students and high school biology teachers wrote comments than did scientists, academics and the public. Interestingly, more public wrote comments than scientists. There were some common reasons given, and these could be shown in the table separately, whereas some less common comments were grouped with similar comments, so that in Table 4-3 a total of 14 categories are presented. To give a further idea of the comments, some typical comments for each category are listed below (from public respondents unless indicated "t"=teachers or "a"=academic). The organisms that they were cited for are indicated (H-human cells, P-plants, M-microbes, A-animals, All).


Table 4-2 Acceptability of genetic manipulation on different organisms

Sample:
Public
Students
HighSchool Biology Teachers
Total

Academics
University of Tsukuba Staff
Total Scientists
Number509 196222 691249 535

Q7b: Human cells
Acceptable26.0 39.846.6 50.133.9 54.6
Unacceptable74.0 60.253.4 49.966.1 45.4

Q7b: Plants
Acceptable80.9 84.587.8 91.286.0 92.5
Unacceptable19.1 15.512.2 8.814.0 7.5

Q7b: Microbes
Acceptable72.8 78.982.4 87.179.2 89.9
Unacceptable27.2 21.117.6 12.920.8 10.1

Q7b: Animals
Acceptable54.2 64.475.6 72.359.7 76.9
Unacceptable45.8 35.624.4 27.740.3 23.1

Figure 4-1 Comparative acceptability of genetic manipulation in Japan and New Zealand
New Zealand data from the survey of Couchman & Fink-Jensen (1990).


Open comments to Q4a
Unethical
"I don't think it is humane"(A)
"To take advantage of animals for human profit" (A)
"No need of course to say about the ethical problems, and there will be too much effect to society in general, especially legal problems" (H)
"It's bad to play with animal genes because of human selfishness" (A)
"Nuisance to animals" (A)
"Whether it is ethically correct or not? Who judges the changing moral standards (with culture, time, politics, and the majority is not always correct). How to face research which is unpredictable?" (All, +unknown)
"Should we use animal genes, because animals have the same life as humans" (A)
"An ethical consensus is needed" (H)
"It may be able to solve hereditary disease, but it means human being has 'the hand of God'. We should solve ethical problems before doing that" (Ht)
"Ethical philosophy about the dignity of life hasn't been established yet, and these types of problems cannot be solved" (HAa)
"Ethical standards are needed" (HMAa)
"Complete lack of ethical consideration" (HAa)
"After enough discussion on the ethics" (Ha)
"It's against bioethics" (Ha)
Fear of unknown, Unknown area
"Now is not the time to use gene technology for people, we need more animal experiments" (H)
"I'm suspicious whether it will produce a good result for human beings" (H)
"Unpredictable result" (H)
"It's still an unknown road, worried about failure" (H)
"Haven't got assurance of basic research, so it's dangerous" (H)
"Unpredictable problem" (H)
"I don't know the context very well, but something strange will happen" (HA)
"Because we don't know enough about human genes yet" (Ha)
Playing God, Against God
"All living things are created by God. The area of study to operate the genes of organisms is a taboo area. If scientists do this we will always go to evil. We'll regret the result in the end. You may laugh this away, but I think that scientists and engineers should not go into this area."(All)
"It's against God"(H)
"We can't control God's program" (H)
"Profanity to the dignity of life" (HA)
"I'm against controlling the ability (spirit and physical) of creatures which have the possibility to have ability or will" (HA)
"Natural is better because human is only a product of the earth. Can you determine that the future in which science rules humans doesn't come?" (H)
"Human beings are only one creature of the earth, to artificially change the natural circle will lead to the destruction of the earth" (All)
"Profanity to God for human beings to make human beings" (H)
"Against nature and heaven's road" (H)
"Religious reasons" (Ht)
"You lose the dignity of life" (Ht)
"Profanity to the creator" (Ha)
"The evolution of animals resulted from natural selection repeated over a long time to adjust themselves to the circumstances where they live. Human beings are imperfect, unlike God. Genetic manipulation carried out by imperfect humans, even if the purpose is good, will give an unpredictable result, we do not know if the result of manipulation is good or not" (HMAa)
"Disrespectful of human beings" (Ha)
"It is God's area" (Ha)
"Human beings are different from animals" (Ha)
Unnatural
"All the best are in nature"(HPA)
"We may make some profit, but its against nature" (A)
"I don't think it's good for science to invade the territory of the evolution of living creatures"(All)
"Everything on earth goes best in the course of nature" (All)
"It's better to be natural. If we adjust to humans' convenience something will go wrong" (All)
"You should respect the speed of evolution of nature, because I don't think we can decide forever what is wrong and what is right and who should judge" (HMA)
"Genes are something which carries each creatures' culture. On one side, to manipulate these may bring some benefit, but it is better not to. If people didn't do this there is a natural function, and human existence itself affects this." (All)
"Because I object to doing it on humans" (H)
"I want natural human beings" (H)
"Try not to profane natural law" (All)
"No good to be against nature, like sex selection" (H)
"It violates the law of nature, but it's acceptable to apply for medical use, such as a remedy for genetic disease" (H)
"Being natural is best" (Allt)
Feeling
"Many people don't know why gene manipulation is necessary yet"(H)
"Without knowledge about it I feel uneasy"
"Worried about the harmful side" (H)
"Somehow" (H)
"It sounds like human experiments" (H)
"Imagining it is already scary" (A)
"If it is a plant there is benefit such as growing plants in bad soil, but I can't see the necessity of manipulating animals at present" (A)
Humanity changed
"It makes human beings uniform and its against nature"(H)
"Will destroy the construction of human society"(H)
"We each have personalities and are different from animals"(H)
"Possible to violate personalities"(H)
"Afraid of people being robots" (H)
"Human which is not human is made" (H)
"People's heart will be lost" (H)
"Results in social chaos" (H)
"Will distort the essence of humans" (Ha)
"Technology will be applied for the denial of human beings" (PMAa)
"Possibility of human not to be a human" (Ha)
"Will lose human dignity" (Ha)
Insufficient controls
"It's up to the personalities of scientists" (H)
"To establish limitations is necessary, but it will not be perfectly followed"(H)
"People's consensus has not been obtained for human cells" (H)
"Because I don't think they will only stop at treating disease with genetic manipulation" (H)
"I agree from the aspect of bioproduction by biotechnology, but especially when we utilise microbes considerable supervision is required" (PMAt)
"I fear the generation of organisms which are harmful to human activity. If we utilise these techniques we need a public institution to check the safety" (PMAt)
"At the moment there is a lack of social or religious consensus in Japan" (Ht)
"Because it is difficult to supervise modified organisms" (Mt)
"Dangerous until the country agrees and decides the regulations on who does what and how" (H)
"I agree, with the proviso at the level of research, but we must carefully consider what we obtain from the manipulation at the level of practical use" (HMAa)
Human health effects, new human diseases
"It's possible to make an organism which has a bad influence on us and spreads widely" (H)
"There's a fear that a disease-causing germ will be born" (M)
"Bad effect on the body" (Ha)
"As food, worried about affect on body" (Pa)
Disaster, out of control, Dangerous
"Gene manipulation of higher animals has very many risks. It's against God from the religious point of view" (HA, +Playing God)
"Because it's dangerous" (H)
"Possibility of making a fatal error" (H)
"If you make one mistaken step it's destruction" (H)
"Against nature and unpredictable outcome and you can't go back if its a bad effect" (HMAa)
"There is more danger (Q7d) than benefit (Q&c), so no need to artificially increase species or kinds" (Alla)
Ecological and Environmental effects
"Put nature out of order" (All)
"I'm uneasy about bad influences on ecology" (All)
"Effect on the ecosystem" (H)
"Don't want to change the ecosystem any more" (H)
"Ecosystem on earth will be destroyed" (A)
"Danger of earth's existence" (PMA)
"Destruction of nature" (PMA)
"Science always has failure, don't destroy nature by science" (All)
"Destruction of natural cycle" (All)
"Destroy the ecological circulation" (Aa)
"Destruction of nature by human beings, especially with humans or microbes you cannot do concrete experiments and predict what effect on nature it has, including human society" (Alla)
Biowarfare
"Misuse for chemical weapons" (M)
"In Japan democracy is immature and some people have been trying to change constitution article 9. In this situation these could be used for dangerous purposes such as biological weapons" (PMAt)
Danger of human misuse
"There's a lack of understanding about it's compatibility with human rights" (H)
"To treat disease is OK, but things like making the body bigger is not" (H)
"If it's only for improvement of livestock it is OK, its not good to change animals in nature" (A)
"There's a danger to misuse it" (All)
"There is a danger that some people use these techniques for immoral purposes" (H)
"Animal which is not an animal is made" (A)
"Soon in the future, misuse will be made" (A)
"Except for genetic disease, leave it" (H)
"I don't have any strong religious objection and it light of the world's progress it may be OK. The problem is the Japanese situation and the researchers doing the experiments, the users have big responsibility" (All)
"We cannot deny the possibility that it may be badly used" (Ha)
"If companies do it, it will go in the wrong direction" (MPAa)
Eugenics, Cloning, Human reproduction
"There may be an uneven sex ratio" (H)
"Will be trouble with too many people" (H)
"If only good genes, only the same type of people are made" (H)
"Fear of people making clones, used by bad politician" (H, +misuse)
"To control cancer disease is OK, but not good if only for inferior genes" (H)
"It leads to discrimination" (H)
"Desired human selection" (Ha)
Deformities, new plant and animal disease
"There is a possibility that a monster-like animal will be made" (A)
"Deformity, and effect on the next generation" (A)
"Deformity or strange thing" (H)
"Person who has an unlucky destiny might be born" (H)
"Humans and animals are highly evolved so the probability of being deformed is high. We can't take the responsibility in such a case" (HAa)
"Bad effect will be inherited" (Ha)
"We have responsibility to children born with abnormality" (Ha)

Table 4-3 Reasons given for unacceptability of genetic manipulation

The values are expressed as %'s of the respondents who answered that it was unacceptable in Q7b (number given in the table). Values written in small figures are those obtained in New Zealand (Couchman & Fink-Jensen 1990).

Reason:
Sample
Human cells
Plants
Microbes
Animals
Unethical, Bioethics Public16 6.8 1.00.7 35 6.6
Student24.6 6.77.3 10.1
Teacher43 17.9 0 3.7 0 2.6 33 3.7
Acad.13.4 1.61.1 9.5
Scient.8 13.3 2.50 12 9.9
Fear of unknownPublic 8 8.4 11 9.3 16 7.5 8 10.5
Student9.3 16.717.1 14.5
Teacher11 13.7 22 7.4 12 10.3 18 11.1
Acad.14.5 14.814.6 11.1
Scient.10 14.6 13 15.0 17 16.7 18 10.7
Playing GodPublic 14.912.3 9.711.0
Student16.1 23.319.5 13.0
Teacher8.5 7.45.1 5.5
Acad.9.6 1.63.4 5.8
Scient.10.0 03.7 6.5
Unnatural,Public 28 17.3 35 24.7 22 20.1 22 21.1
Interfering with nature Student9.3 10.07.3 11.6
Teacher10 6.8 26 18.5 8 12.8 16 14.8
Acad.7.3 19.712.3 3.7
Scient.8 6.3 15 15.0 8 13.0 14 10.7
FeelingPublic 6.89.3 9.07.0
Student9.3 10.09.8 11.6
Teacher0.9 00 1.9
Acad.4.1 1.64.5 6.3
Scient.4.2 2.53.7 6.6
Humanity changedPublic 4.30 0.70
Student4.2 00 0
Teacher6 3.4 0 0 4 0 2 0
Acad.4.7 1.61.1 2.1
Scient.7 4.2 04 0 2 0.8
Insufficient controls Public7 3.8 8 1.0 10 0.7 7 2.6
RegulationStudents 7.63.3 01.4
Teacher19 9.4 27 18.5 20 17.9 24 13.0
Acad.18.0 3.33.4 7.4
Scient.21 20.0 28 5.0 31 1.9 27 9.9
Human health effect, Public5 1.1 03 3.7 0.4
New human diseases Student2.5 04.9 1.4
Teacher3 1.7 0 3.7 20 7.7 2 1.9
Acad.3.2 3.32.2 3.2
Scient.2.1 3 0 2 5.6 4 1.7
Disaster, out of control Public16 7.0 12 3.1 12 6.0 9 5.7
Long term effectStudents 8.513.3 14.611.6
Teacher12 4.2 21 14.8 42 25.6 18 9.3
Acad.3.8 8.212.3 6.3
Scient.14 4.2 21 7.5 35 16.7 20 6.6
Ecological Effects Public7.8 12 26.8 18.712 14.5
Environmental Effects Student4.2 13.312.2 7.2
Teacher0 2.6 18 18.5 4 10.3 0 13.0
Acad.2.9 19.714.6 9.5
Scient.0 1.7 21 12.5 6 13.0 2 8.3
BiowarfarePublic 00 00
Student0 00 0
Teacher0 3.72.6 1.9
Acad.0 00 0
Scient.0 00 0
Danger of human misuse Public9 4.1 8 3.1 13 2.2 6 3.9
Student4.2 02.4 4.3
Teacher12 12.8 3 11.1 14 10.3 7 7.4
Acad.9.3 8.27.9 6.3
Scient.11 9.2 10 10.0 19 5.6 12 6.6
Eugenics, CloningPublic 5 5.1 00 0.4
Student2.5 00 1.4
Teacher10 8.5 0 0 0 0 0 0
Acad.4.9 00 2.1
Scient.5 5.0 00 2.5
Deformities, mutations Public3 2.4 1.00 2 1.3
New plant or animal Student0.8 00 0
diseasesTeachers 2 2.6 3.7 0 2 3.7
Acad.2.9 06.7 2.1
Scient.2 2.0 3 0 0 0 6 0.8
Not statedPublic 9 26.8 25 25.8 33 35.8 10 30.3
Student15.3 23.319.5 23.2
Teacher17.9 22.220.5 27.8
Acad.27.6 39.333.7 30.7
Scient.3 28.3 3 50.0 4 38.9 4 33.9
Number who said it was Public758 370 208 97 241 134 610 228
unacceptableStudents 11830 4169
Teacher97 117 14 27 34 39 45 54
Acad.344 6189 189
Scient.79 240 39 40 52 54 49 121

Figure 4-2 Schematic summary of the reasons given for the unacceptability of genetic manipulation, in response to Q7b, in Japan and New Zealand


There is similarity between the responses given to Q7b (Table 4-3), and the responses given to Q7d, which are listed later in Table 4-7. Some of the comments are grouped differently in Table 4-7, in order to present more of the diversity of thought.

There was a reasonable diversity of replies. For genetic manipulation of human cells the most common responses were that it is unethical, there is the danger of human misuse, eugenics and insufficient controls; and the reasons such as it is unnatural, it is playing God, or the fear of the unknown. In the reason "fear of unknown", most respondents were concerned that there may be unknown results, rather than it being an unknown "area" of research.

The results are comparable to those obtained in New Zealand, as can be seen from the values in Table 4-3, and these are summarised in Figure 4-2. The New Zealand values given in Table 4-3 are only approximate guides, but it is useful to make a comparison. When a New Zealand value is missing, it is because it was not given in the results of Couchman & Fink-Jensen (1990). The following groupings were used (if not obvious from the categories listed): In the results from New Zealand, the reasons "playing God", and "unnatural", were combined, under the comment "unnatural" the reasons "danger of human misuse", and "biowarfare" were combined into "Danger of human misuse" and there were varying frequencies (5-15%) of "other" comments, that are not put in any category in Table 4-3. In Japan these comments were scored separately. All the reported comment categories in the New Zealand results were used for defining the categories for scoring the comments of the Japanese respondents, and they were grouped in the table, as described above. Additionally several other new categories were used for the Japanese comments.

The most frequent reason why teachers did not accept genetic manipulation of human cells was because they thought it was unethical, or there were ethical problems. There was a comparatively low level of concern expressed about ethical problems when using animals in Japan. There were also significant proportions of respondents who thought that genetic manipulation was interfering with nature, or that it was profanity to God. These respondents may see these techniques as unacceptable, regardless of the state of technology and regulation. Although many scientists react to people with these views as irrational, it is noteworthy that about 16% of the scientists and teachers in New Zealand and Japan who found these techniques unacceptable also shared these views. In a public opinion survey in Japan in December 1985 (N=7439, PMO 1986a), people were asked about the relationship between nature and human beings, and chose between four options. 51% said we should use natural systems for human beings, 29% said it is bad to do artificial things so we should leave things to nature, 18% said humans can control creatures or nature, and 12% didn't know. The results of the present survey are consistent with these.

As has been noted in some major biotechnology science journals (Dixon 1991b), supporters of genetic manipulation should accept that people may reject these techniques for what the supporters see as irrational reasons, no matter how knowledgeable they are about the techniques. There is the commonly held view in Japan that when people understand the technology they will accept these things, however, as found in all countries, many people continue to hold these type of views and reject new technology even when they understand it. Although to fight disease is against nature, yet we all do it, there are limits in people's mind to interventions in nature. It is better for the supporters of the use of these techniques to try to understand these views, which many of their scientific peers also hold, than to continue to focus on attempts to change such views.

As will be seen in the responses to Q13 and Q14, in chapter 7, which asked people whether they would use gene therapy, the majority do accept the use of human genetic manipulation for curing serious genetic diseases. Q7 was a general question and was expected to show lower approval of genetic manipulation on humans than the specific questions.

In general the other frequently cited comments in all samples for all topics were connected with the unknown nature or danger (disaster) of the results. There was also much concern about insufficient controls, especially by teachers and scientists. If what are seen to be safe and adequate controls are established, the people who had these reasons for objecting to genetic manipulation, may accept it. As noted below, there was also qualified acceptability by some respondents, depending on the introduction of appropriate control measures. It is up to the researchers to prove that the results represent an acceptable level of risk, and to adjust regulatory procedures to those that are seen to be adequate. A discussion of the regulation of biotechnology is in section 8.4.

There was also concern about human misuse of these techniques, which again, could be eased by further guarantees over who uses these techniques. For human beings, another major response was concerns about eugenics, and cloning. These fears may be eased by the introduction of laws, but we should note that in Europe where there are some laws to prevent such abuses, there is still much concern with eugenics (see section 4.4).

In addition to the respondents who said that genetic manipulation was unacceptable because there were insufficient controls, there were also some respondents who said that it was acceptable providing there were controls. These were a sizable number and are shown in Table 4-4. The actual number of respondents who were concerned about controls should include these respondents in addition to those who said that the area was unacceptable because of insufficient controls. It may have been useful to ask respondents for their reasons for both response options to Q7b-d, as a few respondents remarked. It may be significant that such a high proportion of respondents who said that the techniques were acceptable, did spontaneously write down some qualification to their response choice. Less students wrote such comments, in contrast to the general trend in the answers where more students gave reasons when asked for them, which suggests either that they were not very concerned that extra controls were necessary, or that they were still young and used to answering exam questions in a rigid way therefore were not so forthcoming with additional remarks.

Some of the comments were:

"If, and only if, a biological method which is consistent with ethics is established" (H)
"It depends on conditions" (All)
"I don't know what I should say because of a lack of knowledge, but I feel uneasy to operate the gene (HA, not stated)
"Maybe not dangerous if there is strict control so that only people who have good judgement (common sense) do it" (All)
"It's OK, depending on the animal" (A)
"We can't help but do this because of future ecological necessity" (PMA)
"Some cases are good in some situations, for example, treating genetic disease is OK" (H)
"It is necessary for treating genetic disease, but I'm a little worried" (H)
"Be limited to somatic cells" (H)
"Need regulation of extensions and context" (PMAt)
"But, need to sufficiently consider the secondary influences" (Alla)
"So-called molecular disease can be treated, but not for enhancement (lengthening life and increasing intelligence)" (Ht)
"With the condition that these are done in an ethically permissible range" (Alla)
"But, except for germ cells and embryos" (Ha)
"I think if it doesn't disturb bioecosystems it can be used" (Alla)
"It needs strict regulations" (Ha)
"If uncontrollable event is predicted, we shouldn't use it" (Alla)
"Needs sufficient control" (Alla)
"But on one condition, that we don't break the ecosystem" (PMA)
"It is necessary to do under the control of a committee which includes third party" (Alla)
"Under the condition that everything has a proper scientific purpose and everything is published" (Alla)
"Can use, but it's important to keep ethical and social agreement, all science and technology should be used for society and should be ethical for humans" (Alla)
"Depends on animal type" (Aa)
"Establish ethical thinking first, limited fields only" (Ha)

Table 4-4 Conditional acceptability of genetic manipulation

The proportions of respondents who said that genetic manipulation was acceptable, but wrote that limits were required. The values are expressed as %'s of the respondents who answered that it was acceptable in Q7b.

Sample
Human cells
Plants
Microbes
Animals
Public20.6 1.71.9 8.5
Student11.5 1.20.7 0.8
Teacher24.5 6.77.7 7.8
Acad.19.1 6.67.0 9.1
Scient.19.0 6.97.1 8.7


4.3. Perceived Benefits of Genetic Manipulation

The results of Q7c, which asked people whether they thought there were benefits of genetic manipulation, are summarised in Table 4-5. Both plants and microbes were perceived to give the most benefit, with genetic manipulation of animals significantly lower. However, still more than 70% of teachers and scientists saw a benefit from genetic manipulation of animals. There were less benefits perceived from human genetic manipulation. Teachers and scientists saw more benefit from these techniques than the public or students. More New Zealanders believed that there would be benefits from genetic manipulation, especially for animals and plants, and the comparative results are represented in Figure 4-3.

The question was phrased to include benefits to the country. Some respondents wrote that the question should not be limited to national interests (see the examples of comments). Of course this is true, and it is in fact encouraging that some people noted this point, reflecting some concern that benefits of technology should be for all people of the world. This topic will be discussed in chapter 5, it is a more complex question to answer this general question in terms of the whole world, than many people imagine.

The perceived benefits were also asked, and these are summarised in Table 4-6. The method used to analyse the reasoning was to assign the comments to categories, as was done for Q7b, described above. A total of 37 different categories were used in the computer data analysis. Although a variety of comments was written, generally they could easily be assigned to categories. For each distinct reason given in the comment, a count of 1 was scored in the appropriate category of the data sheet in the computer. The most reasons given for a single answer was 4, but generally there were only 1 or 2 comments. Also, a high proportion did not write any comment, as is shown in Table 4-6. Teachers and students showed the highest response, but unlike the reasons for unacceptability, scientists listed more benefits than the public. There were some common reasons given, and these could be shown in the Table separately, whereas some less common comments were grouped with similar comments, so that in Table 4-6 a total of 14 categories are presented. To give further a further idea of the comments, some typical comments for each category are listed below (from public respondents unless indicated "t"=teachers or "a"=academic). The organisms that they were cited for are indicated (H-human cells, P-plants, M-microbes, A-animals, All).


Table 4-5 Perceptions of benefits and risks from genetic manipulation

Sample:
Public
Students
HighSchool Biology Teachers
Total

Academics
University of Tsukuba Staff
Total Scientists
Number485 192221 660227 518

Q7: Human cells
No Benefit62.3 47.946.5 43.654.8 39.2
Benefit37.7 52.153.5 56.445.2 60.8
No risk16.7 10.114.4 26.614.7 29.2
Risk83.3 89.985.6 73.485.3 70.8

Q7: Plant cells
No Benefit21.1 15.113.2 13.718.1 12.0
Benefit78.9 84.986.8 86.481.9 88.0
No risk60.5 40.045.3 56.048.0 57.1
Risk39.5 60.054.7 44.052.0 42.9

Q7: Microbes
No Benefit31.5 24.919.5 16.724.5 13.5
Benefit68.5 75.180.5 83.375.5 86.5
No risk46.4 25.830.4 46.336.8 48.3
Risk53.6 74.269.6 53.763.2 51.7

Q7: Animals
No Benefit46.9 38.729.0 29.640.0 25.7
Benefit53.1 61.371.0 70.460.0 74.3
No risk38.7 27.431.3 42.129.3 45.7
Risk61.3 72.668.7 57.970.7 54.3

Figure 4-3 Comparative perceptions of the benefits and risks of genetic manipulation in Japan and New Zealand
Data from New Zealand from the survey of Couchman & Fink-Jensen (1990).


Examples of open comments from Q4c
Cure genetic disease, prevent genetic disease
"Useful to cure genetic disease" (H)
"Curing genetic disease" (H)
"It may be good to cure hereditary disease and improve the human constitution" (H, + Increased quality)
"We can keep our health longer if we change harmful genes into good ones" (H)
"Prevention of disease that we screen beforehand for" (H)
"Provide healthy life by treating genetic disease and geriatric disease" (H)
"If we can treat bad genetic disease it's good" (H)
"Possibility of getting rid of bad genes and only having good ones" (H)
"Avoid inheriting genetic disease and treat molecular disease" (Ht)
"For those who have unfortunate genes" (Ha)
Disease control
"Many products which are disease resistant and grow fast" (P)
"Can get rid of noxious agents and exterminate natural enemies" (M)
"Good to cure disease" (M)
"Prevention against disease" (A)
"Extermination of cancer or AIDS" (M, + cancer cure)
"Research disease-causing germs" (M)
"Development of methods against viruses" (M)
"Development of medical cure" (H)
"Treatment of disease" (H)
"Development of vaccines" (M)
"Disease treatment and keeping health" (Ma)
"To get resistance to disease" (Aa)
"Disease resistance and high yield varieties" (Pa, + high yield)
Medical advance, cancer cure
"Treatment of cancer and disease" (H)
"Extermination of cancer" (H)
"Progress of medical science" (M)
"It's OK from the medical point of view" (H)
"Improve medical care" (A)
"Especially in the medical field, development of vaccines" (M)
"Disease research, cancer research" (M)
"Not to make an unhappy child" (Ha)
"Search for cancer cause" (Ha)
Scientific knowledge
"Some benefits for all human beings which depend on the development of science, and some economic benefits from mass production of cheap products from genetic engineering" (All, +Economy, +Make useful substances)
"Good to promote research with benefits for disease and food" (A, + food, + medical advance)
"To clarify biological functions" (MA)
"Human gene experimentation" (A)
"Instead of human beings can use animals as guinea pigs" (A)
"Whether genetic engineering is good or bad is a different problem. Our country has a top class GNP so it has a duty to lead medical research. Other countries would consider it a contribution to the world. This is only the majority view" (All)
"Progress of biotechnology" (M)
"Essential for genetics and biotechnology" (M)
"Japanese prosperity is based on science, and Japan has vast money, so Japan should allow even study which brings no benefits" (Allt)
"It is useful as a method of research to study the function of genes in one plant" (Pa)
"Building up the foundation of science and the application of science and technology"(Alla)
Agricultural Advance
"Agriculture and forestry development" (P)
"Microbes involved in early steps of food chain are also useful for the life of other animals" (M)
"Agricultural revolution" (PA)
"Develop livestock, and fishery, and human medicine" (A, + medical advance)
"Improve the efficiency of agriculture" (Pa)
"Lighten the agricultural work" (Pa)
Different varieties
"Can make plants or crops which are cold or drought resistant" (P)
"Crops that are protected against insect pests" (P)
"It may create varieties adapted to various environments, and those which produce abundant crops" (P)
"Can get some crops (vegetables and fruits) not influenced by the weather" (P)
"Effective to breed animals" (A)
"New species which are resistant to disease and insects" (P, + disease control)
"Making new varieties of livestock" (A)
"It's OK if useful for improving varieties of vegetables and fruit" (P)
"Can make various vegetables or flowers" (P)
"New plants and microbes" (PM)
"Development and creation of useful varieties" (PMA)
"Make varieties which are disease resistant, bad weather resistant, and can be harvested a lot" (P, + disease control)
Increased yield to make more food
"We can grow a lot of animals for foods quickly" (A)
"Big quantity of milk and meat, etc." (A)
"Various types of delicious food variety made in big quantity" (P)
"Stable supply of food" (P)
"Agricultural product which has big harvest" (P)
"Increasing the agricultural products (P) and producing food and medicine" (M)
"Stable supply of food" (PMA)
"Effective production by changing varieties" (P)
"Food chain will become better" (Mt)
"Using these techniques there are various benefits, such as increasing production and environmental security, but these should be done by people with common sense" (PMAa, + environment)
"To solve the food problem" (Pa)
Humanity benefits, Whole world benefits, Living standards increase
"Developing and increasing variety of livestock which has low cost" (A)
"Unlimited possibility for Japan which has few materials or land" (P)
"The problem of increasing population" (H)
"Too many people in the world, so we can solve the food problem" (PA)
"New consumer products developed" (PMA)
"If there is a food crisis people will kill each other, so this is better" (P)
"Make more food, increasing the % of food which is self produced, and then export to countries where people are dying of starvation" (All)
"We must consider the beneficial uses not for Japan but for human beings" (PMA)
"I believe there are different types of benefit to the whole world" (Alla)
"Not only Japan, but we should develop scientific technology to benefit all" (Alla)
"Not only Japan, but it's possible to bring benefit to all people, including food and treating disease" (Alla, + production, + disease control)
Exports increase, Economy
"For the economy" (All)
"Might change the situation of too much imported food" (PM)
"Increases production quality and enlarges the proportion of the demand that can be supplied from within the country" (PMA)
"If successful, Japanese power will be bigger" (All)
"Economic benefit" (All)
"It can make many good plants" (P)
Increased quality, beautiful product
"It can make many good plants" (P)
"Good meat" (A)
"Diversity from changing pigments or shape" (P)
"Brings us tasty daily food" (P)
"Will bring a better crop" (P)
"Improvement of human character" (H)
"Supply with better food" (PA)
"Useful to improve food or something" (M)
"Possible to make new nutritious food" (P)
"Increasing quality" (PA)
"Better tasting vegetable, etc." (P)
"Can grow leafy plants (for show), close to us" (P)
"Big livestock for food" (A)
"As far as vegetables and flowers are concerned, better things will be made" (P)
"We can make more Carl Lewis's" (H)
"Improvement of livestock" (Aa)
Environmental advantage
"It's important to develop the microbe to improve water quality" (M)
"Can create a microbe to decompose waste substances" (M)
"For appreciation and to recover endangered plants in nature" (P)
"Preservation of animals" (A)
"Save endangered animals" (A)
"Keep natural plants' gene" (P)
"Helpful for environmental protection and improvement" (M)
"Make microbe to stop sea pollution" (M)
"Might be useful to treat rubbish" (M)
"To improve the soil and keep underground water safe" (M)
"Increase the harvest and safer because no pesticide" (P)
"Non-waste vegetables, cheaper and less rubbish" (P)
"For the security of nature, if we make a good result it's good" (PM)
"Transition to more environmentally friendly technologies than the chemical industry" (PMAa)
Make medicines
"Production of medicines" (M)
"Synthesis of new medicines" (M)
"Mass production of new medicines" (M)
"I have the image that good quality medicine will be made" (M)
"Can make lots of antibodies" (M)
"New medicines will be made by new microbes" (M)
"Make hormones" (M)
"Make insulin" (M)
"Could be effective in the pharmaceutical and medical fields" (M)
Make useful substances, Industry
"It's effective to produce useful substances, medicines, etc." (PMA)
"Make medicine and chemical products" (M)
"Mass production of useful substances" (M)
"Efficient production of useful substances" (PMAt)
"Production of various substances" (Mt)
"Development of bioreactor and mass production of bioproducts" (MAa)
"Useful for production of useful chemicals utilising microorganisms" (Ma)
"For example, amino acids, protein, useful substances" (Ma)
"To make plants which produce useful things and apply these to medicine" (Pa)
"Production of special substances in high purity" (Ma)
"Contribute to industry" (PMAa)
Doubtful benefit
"It'll bring Japan some merit, but it's not always good to use" (All)
"For example, improvement of breed etc., but it is not always good for people" (P)
"Possibility of useful thing for human being, but also risk of destroying the ecosystem, so I can't say either" (PMA)
"Can already see the bad effect of seeking only Japan's benefit" (All)
"Benefit if used in a good way" (All)
"On one side there is economic benefit, but there is also demerit" (All)
"But I doubt that these are profitable over a long term perspective" (Allt)
"In the short term a benefit, in the long term?" (PMAa)
"If companies seek benefit, will it bring us a good result?" (PMA)
"It may only be a benefit to certain people financially" (Alla)

Table 4-6 Benefits of genetic manipulation cited by respondents

Values are expressed as %'s of the respondents who thought that there were benefits (number written in table). Values written in small figures are those obtained in New Zealand (Couchman & Fink-Jensen 1990).

Reason:
Sample
Human cells
Plants
Microbes
Animals
Human genetic disease, Public22 22.8 0.50.3 0.4
cure or preventStudents 30.90.6 0.72.6
Genetic diseaseTeachers 50 47.8 0 0 2 0 0 0.7
Acad.39.5 00 0.2
Scient.38 40.8 0 0 0 0 0 0
Disease controlPublic 31 14.8 2 3.4 27 3.5 16 2.4
Student23.7 6.14.9 6.1
Teacher12 19.5 44 7.3 17 2.2 33 5.3
Acad.19.5 6.02.3 3.4
Scient.20 19.9 38 7.2 9 2.2 27 3.7
Medical Advance,Public 18 8.5 2 2.4 13 15.6 3 5.2
Cancer cureStudents 18.54.3 10.614.0
Teacher28 17.7 20 3.1 4 13.5 8 8.6
Acad.12.6 2.610.1 6.0
Scient.58 11.8 3 1.9 23 8.2 6 6.0
Scientific knowledge Public7 1.7 0.310 2.2 6 3.6
Student4.1 2.54.2 7.0
Teacher1 6.2 4 4.2 1 5.6 2 9.9
Acad.5.0 3.24.7 9.7
Scient.2 5.2 2 3.7 8 5.3 3 11.0
Agricultural Advance Public0 22 2.6 13 1.6 10 0.8
Student0 6.12.8 2.6
Teacher0 24 9.4 25 3.9 14 6.6
Acad.0 4.11.4 2.4
Scient.0 22 4.3 30 1.8 10 3.7
Different varieties Public0 20 14.6 2.913.3
Student0 20.22.1 8.8
Teacher0 30 31.9 0 4.5 15 28.9
Acad.0 24.110.4 20.9
Scient.0 24 25.2 6.713 22.2
Increased yield to make Public1.1 23 21.5 7.316 15.7
more foodStudents 025.2 7.715.8
Agriculture, FoodTeachers 042 26.2 0 9.0 39 17.1
Acad.0 25.710.1 18.3
Scient.0 47 25.8 10.538 18.3
Humanity benefits, Public22 13.1 3 10.2 9 11.4 6 12.9
Whole world benefits, Student10.3 11.014.8 13.2
Living standard increases Teacher4 3.5 0 5.8 0 8.4 0 10.5
Acad.9.3 7.08.0 7.7
Scient.11 9.1 1 6.9 6 8.0 2 8.1
Exports increase,Public 4 6.3 9 4.5 2 5.7 11 6.9
EconomicsStudents 3.15.5 5.63.5
Teacher0 0.9 3 0.5 9 0.6 9 0.7
Acad.1.6 5.05.6 4.5
Scient.2 1.6 11 4.3 5 5.3 14 3.9
Increased quality, Public5.1 (38) 12.3 3.8(49) 9.7
Beautiful productStudents 06.7 04.4
Teacher0 0 (22) 4.7 0 0 (40) 2.6
Acad.1.4 3.91.8 4.1
Scient.1.3 (26) 3.9 2.0(45) 4.7
Environmental Public 04.6 11 7.6 2.8
advantageStudents 1.05.5 8.51.8
Teacher0 2.1 2.20.7
Acad.0 5.85.9 1.9
Scient.0 5.96.2 1.3
Make medicinesPublic 00.3 6.70
Student0 0.610.6 3.5
Teacher0.9 028.7 0.7
Acad.0.3 0.510.4 2.4
Scient.0.3 0.710.7 2.6
Make useful substances, Public0.6 1.63.5 3 1.6
IndustryIndustryStudents 2.14.9 12.04.4
Teacher0 3.1 58 18.4 2.6
Acad.0.8 3.921.6 6.2
Scient.1.0 4.846 23.6 7.0
Doubtful benefitPublic 1.10.8 0.60
Student0 00 0
Teacher1.8 1.01.1 0.7
Acad.1.6 1.01.1 1.1
Scient.1.3 0.90.9 0.8
Not statedPublic 20 35.2 8 38.2 30 39.7 14 37.9
Student19.6 25.530.3 30.7
Teacher16.8 20.921.3 21.1
Acad.24.4 31.031.5 31.4
Scient.3 23.9 4 29.5 6 30.1 5 29.8
Number who answered Public638 176 1250 382 523 315 930 248
that there was a benefit Student97 163142 114
Teacher113 113 257 191 216 178 199 152
Acad.365 588556 465
Scient.94 306 213 461 172 449 177 383

Nearly half of the teachers who said there was a benefit from genetic manipulation of human cells said it would lead to cures for genetic disease, and there were also many who put another medical benefit as their reason. From plants and animals, the major perceived benefit was making new and different varieties, and increased yield to make more food. The category "agricultural advance" was only used for those that said there was an agricultural advance in general, and if they specified new varieties of plant or increased food production as a benefit, only these reasons were scored. The largest benefit seen for genetic manipulation of microorganisms was to make medical products such as hormones, and other useful substances. The comments were scored, depending on whether the respondent listed only a medical product, in which case they were not scored for the general "production of useful substance" category. Only if they listed an industrial product or other useful substance was it scored in that general category (see the examples).

The results from the New Zealand survey conducted by Couchman & Fink-Jensen (1990) are also shown in Table 4-6, and these are schematically represented in Figure 4-4. The New Zealand values have been rounded off to the nearest integer, but are useful guides. The results are very similar in general. Half the teachers in both countries saw the benefit of curing or preventing genetic disease from genetic manipulation of human cells. In Japan almost all the respondents used the word "cure", but in New Zealand almost all the respondents used the word "prevent". This could be related to the use of genetic screening to prevent genetic disease, but it is not possible to be sure if this linguistic difference represents any different thinking, because the English word "prevent" can also mean cure, not only screening.

Other medical benefits, such as disease control, cancer cure, and medical advance, were common for all respondents. The high perception of medical benefits is consistent with the results of Japanese public opinion surveys in which respondents must respond to a list of multiple options. For example in December 1985 people were asked what were their expectations from life sciences (N=7439, PMO 1986a). The responses were chosen from a list; 45% agreed that they would allow treatment of cancer and genetic disease, 13% said pollution could be stopped, 11% said they would increase living standard, 5% said they would lead to new industry, 4% said they would allow us to produce more food, 4% said they would lead to the development of new products and 4% had no special hope, with 13% who "didn't know". In another question looking at expectations, over a 15 year period, 64% said that they expected human disease prevention, 69% said that they thought life would be lengthened, while 49% thought that ideas about the family would be changed and 50% thought that ordinary diet would be changed. In a 1986 general science survey (N=2376, PMO 1986b), 53% of people said that they felt science and technology in medical techniques, 36% said they felt it from advanced scientific technology such as electronics and biotechnology, and 31% said that they felt it from the general quality of life and plentifulness of food.

The most common response in both countries for a benefit from genetic manipulation of microbes was to make useful substances. Economic benefits were at a low level, with more respondents in New Zealand listing these benefits, perhaps because the economy is so dependent upon biotechnology, in terms of agriculture. In the reasons cited for genetic manipulation of animals, many more New Zealanders cited disease control of animals, as a reason. In both countries similar proportions cited "new varieties" or "increased production and food", with a trend for more New Zealanders to cite the later.

The category "different varieties" in the table includes those respondents who cited the benefit of making new varieties, and the benefit of climate resistant varieties. Among New Zealand teachers who saw benefits from plant genetic manipulation, 15% cited "making climate resistant varieties", whereas in Japan only 2% cited this. The difference in the number of people who cited the benefit of "increased quality" of plants and animals between the two countries may be due to drawing a different category boundary, in New Zealand this category included improved strains, or varieties, whereas "improved varieties" were included in the "new varieties" category in Japan, to distinguish that comment from comments "improved quality". In the category shown in Table 4-5, "increased quality" included making a beautiful product, such as ornamental plants, which represented half of the respondents in that category in Japan. In New Zealand, teachers cited about 3-7% "other" comments, and scientists 5-7% others, which were not reported so are not included in Table 4-6.

In the 1983 Nikkei survey of business people in Japan, people were asked what were their hopes from the future of biotechnology (Nikkei 1983). To attempt to determine what benefits they hoped for from biotechnology, they were also asked to respond to a list of benefits, 73% said medical benefits such as a cancer cure, 65% said for developing plant and animal varieties, 25% agreed it would clean the environment, 17% saw benefits in energy and 12% saw benefits in saving energy in the chemical industry. People were also asked whether they thought biotechnology was suitable for Japan, and 69% said yes. This value is much lower than the value of Q5b in the current survey. These people were asked to respond to a list of possible reasons, and 61% agreed because it was intensive knowledge technology, 43% said it was suitable because Japan has no raw materials or energy, 40% said because Japan is good at fermentation technology, 18% said because of future technology development, and 16% said because Japanese are good at miniature technology. In the Dentsu (1985) survey of the public, people were asked to respond to statements asking what was the context of their interest in biotechnology (41% of the total who said that they were interested); 59% said to develop medicine and cure disease, 34% said to increase varieties of plants and animals to increase food production, 21% said to make new varieties to make new foods, 25% said to develop energy sources, 11% said as new materials for the chemical industry, and 21% said nothing special.

In the February 1991 survey by the Agency for the Environment (N=1363, EA 1992) people were asked to chose from a list of responses, the closest response to their ideas on the usefulness of genetic engineering, among the biotechnologies. It should be noted that the people answering this questionnaire had been given several pages of introductory notes to read before answering the questions, which may have affected their responses. 31% chose "it will make new medicines and useful organisms", 35% chose "our country should always actively develop new technology like this one", 23% chose "the history is not yet long enough so its usefulness is not clearly seen", 8% chose "because I'm worried about adverse environmental or health effects, it is not useful", and 2% said something else. Their results are consistent with the results obtained here, but the results of this survey give a better impression of what the people actually think, because there was no prompting in the question. Therefore, the results of this survey should be encouraging for those who want to promote biotechnology, in that many people could think of some benefits from the technology. Actually genetic manipulation may not be the most widely known of the biotechnological techniques, judging from the results of earlier surveys, and the results of Q5, where more people understood biotechnology than those who understood genetic engineering.

In a recent European public opinion poll in the U.K., France, Italy and Germany (performed in 1990 by Gallup for Eli Lily, N=3156, Dixon 1991), the respondents were asked to choose the largest benefit that they saw coming from biotechnology, between one of four possible benefits from biotechnology. Over half rated cures for serious diseases as the most important benefit. Another option was reducing our dependence upon pesticides and chemical fertilisers, which 26% of Italians, 24% of French, 22% of British and 16% of Germans, chose as the largest benefit. The respondents were asked a similar question about their largest concern. 40% of French, 35% of Germans, and 25% of British and Italian respondents chose eugenics, and slightly lower proportions overall chose environmental harm, 34% in Britain, 33% in France, 22% in Italy and 21% in Germany. Potential health hazards from laboratory genetic research were named by 29% in Italy, 17% in France, 11% in Britain and 10% in Germany. Overall one third of respondents feel that biotechnology is ethical and one third feel that it is unethical, and one third think it is in between, "neither".

Therefore, it appears that in all countries medical advances, and the ability to cure genetic diseases are the major benefits people see from genetic engineering and biotechnology. Other benefits are divided, depending on the organisms that are considered. Microorganisms are seen for both medical use and use to produce useful substances in general through fermentation. Plants and animals are seen for their obvious agricultural importance, and genetic manipulation is perceived for its ability to aid the breeding of new varieties, and to increase production of food.

Although in the European survey, discussed above, the choice of the benefit of reduced pesticide use and environmental benefits is popular, it may not actually be a common feeling. The response to Q16f, which asked if people thought GMOs would have this advantage, was supportive (see section 4.5), but from the responses to Q7c in both Japan and New Zealand, it may be very unfamiliar, despite the high level of concern expressed in Q5 about pesticides. In both New Zealand and Japan, there should be more publicity associated with this environmental benefit, though the chemical companies who make pesticides may have different priorities (see chapter 5).


Figure 4-4 Reasons cited for benefits of genetic manipulation

4.4. Perceived Hazards of Genetic Manipulation

The results of Q7d, which asked people whether there were any hazards of genetic manipulation, are summarised in Table 4-4. The level of awareness of techniques of genetic manipulation among people in Japan has increased in the last decade, but as seen in the following results, they still have concerns. This is not surprising at all, when looking at the spread of responses among the different groups. More high school teachers perceived risk from genetic manipulation than did the public, even though more saw benefits coming from genetic manipulation. Scientists gave similar responses to the public, except that they expressed less concern with genetic manipulation of human cells (71%) compared to the public (82%).

More Japanese perceived a possibility of hazards from genetic manipulation than New Zealanders (Figure 4-3). This was especially true for genetic manipulation of humans and animals. Japanese students and teachers perceived more risks than other groups in Japan. There have been no accidents in Japan involving GMOs. In fact there has only been one field release of GMOs, compared to about 20 in New Zealand, and this may be related to the high level of perceived risk in Japan.

People were asked to express the risks that they perceived, and these are summarised in Table 4-7. The method used to assign the cited reasons, was the same as that described for the reasons given for benefits, and unacceptability. A total of 40 categories were used in this analysis, but in Table 4-7, they are grouped in 14 categories. The comments given for some were very similar to those cited for the unacceptability of the techniques, but there were many more total respondents who wrote comments to Q7d than for Q7b, because many people saw some risks. However, the proportion among the respondents who said that there were risks who wrote comments to Q7d, was generally lower than the proportion among the respondents who said that genetic manipulation was unacceptable who wrote comments to Q7b, as in New Zealand. Some people may have thought that they had already written a comment to Q7b, but many of those who said that there were risks but did not cite a risk had answered Q7b with the "acceptable" option. More scientists who saw risks wrote comments to Q7d than the scientists who cited a reason after saying that the techniques were unacceptable in Q7b. As for all the questions, Q7b,c&d, less respondents in Japan wrote comments than those in New Zealand, especially scientists and teachers (who were questioned by mail reply questionnaires in both countries).

To give further a further idea of the comments, some typical comments for each category are listed below, and a detailed representation of the public sample comments is in Figure 4-5. The comments are from public respondents unless indicated "t"=teachers or "a"=academic. The organisms that they were cited for are indicated (H-human cells, P-plants, M-microbes, A-animals, All).


Examples of open comments from Q4d
Unethical, Ethical abuse
"It's against ethics. We may not operate on human beings" (H)
"Human desire is endless. It'll reach immoral use" (H, + misuse)
"Ethical problem" (H)
"Human rights problem" (H)
"More of a problem is Japanese society which discriminates against handicapped people including those with hereditary disease, and dehabilitating diseases" (H)
"Ethical problems and misuse of the technology" (H, + misuse)
"Unethical and not a human thing to do" (H)
"The collapse of ethics because of far-reaching development" (Ht)
"If we were to produce new animals without any restrictions there would be moral problems" (Aa)
"Research and ethical and religious problems" (Aa)
Fear of unknown
"I wonder how dangerous the gene-operated organisms are" (All)
"Can only partly foresee" (All)
"I don't know well enough, but to create a new organism that hasn't been in nature will have some hazards" (H)
"Worried about the effect of manipulation" (H)
"Unknown result" (All)
"I don't think all the questions of science and technology have been solved yet and also new creatures could destroy the ecosystem" (All, + ecology)
"Mistakes will happen" (H)
"New research always has a dangerous side" (All)
"Don't know what is made" (HMA)
"Like a science fiction movie" (M)
"Until the time when the technology has been perfected it is always a danger" (All)
"It couldn't be 100% safe because we make a new species which has not existed in nature" (All)
"It needs a long time to clear the effect (2 or 3 generations)" (HAa)
"Should wait until many things become clearer" (HAa)
Playing God, unnatural, against nature
"It's OK if the nature of the animal isn't basically changed, but I fear the creation of another living thing" (A)
"It's against the natural genetic law" (A)
"Doesn't mean dangerous, just shouldn't do" (H)
"Not what human beings should do" (HMA)
"Shouldn't use animal ecosystem for human benefit" (A)
"The experiment itself, which uses things which have 'life' is already degrading the human heart" (A)
"Because we are not God, we shouldn't create new animals" (A)
"When the border between species is lost" (A)
Danger of human misuse, biowarfare
"There's a danger to advance to the wrong direction, like the atomic bomb" (All)
"It could be abused" (HA)
"There's a danger that it will be put to criminal use" (H)
"A talented scientist who conceals madness may abuse it" (H)
"Abuse by the government leads to use for war" (M)
"Am afraid of a war using some bacteria made by the operation of human beings" (M)
"We cannot always use technology for the right things" (H)
"Worried about the way manipulation is used, artificially and intentionally" (H)
"It leads to human cell manipulation" (A)
"Keen researchers and silly politicians misuse the technology leading to destruction of humans and the earth" (All)
"Some risk of failure during research, and unethical and military uses" (All, + danger)
"Always there are people to misuse" (All)
"Because Japanese use everything for their own benefit, I'm worried about future use" (HMAt)
"It depends on the research system and the posture of researchers" (Allt)
"While science and technology has brought benefit to mankind it also led to the development of nuclear weapons, etc. In pollution problems, it was said that chemistry was the root of all evil. In short, I don't say 'It's dangerous because it's a biological method'. Rather, science is a double-edged sword, it depends on how to use whether these could present risks or no hazard" (Alla)
"To get honour, scholars may make anything, even harmful things" (Alla)
"Misuse by the decisions of a few scientists" (Ha)
"Morals of companies, researchers and politicians" (Alla)
"People may get to like deformed pets, or to make a pet of the ecosystem" (Aa)
"We always make bad use, like pesticide, defoliants and chemical weapons" (Alla)
Eugenics
"It's troublesome if too many clever people are born" (H)
"Danger of making super-ability person" (H)
"It may be put to bad use, beyond curing disease" (H)
"I fear that social positions will be imbalanced because there will be only people of high ability" (H)
"Discrimination of humans made by genetic manipulation" (H)
"The thought that inferior is bad" (H)
"To get rid of handicapped people is scary" (H)
"New way of race discrimination" (Ha)
"Privileged races will come into existence" (Ha)
Cloning, human reproduction abused
"Shouldn't put human hand in human reproduction" (H)
"In Japan and in the world, a different a strange type of people will be made" (HA)
"Parent/child relations won't work and also if individuals which we don't want are made, we can't get rid of them" (H, + deformities)
"Same type of human beings are made" (H)
"Only people like those who researcher's want will be made, selfishly and by human's hand" (H)
"If it is used badly, we will make people like robots and that have no parent" (H)
"Mass production of human beings that are needed by some people" (Allt)
Insufficient controls, need public discussion first
"There is nothing to stop the escalation" (H)
"Basically, I think it is OK to use, but need certain limits. Also worried about the society where only high IQ and healthy people are approved" (H, + eugenics)
"Dangerous, but if you can brake it maybe its OK. If you just worry you can't do anything, need to make strong controls then do it" (All)
"If we don't put any limit some people will do silly things" (All)
"Sufficient discussion is required" (Ht)
"Japanese might utilise them for their further desire because the moral aspects are not sufficiently discussed" (Ht)
"Everything is dangerous, but it depends on how to use and control it"(t)
"In the case of human genetic manipulation there is a danger of the science going forward without discussion of how to live" (Ha)
"We need a social consensus before using" (Alla)
"It is necessary to clarify the purpose and to regulate by law" (Ha)
In Japan the view on biohazard is slipslod so some troubles should happen in the near future, but I cannot explain concretely what will happen" (Alla)
"Need to get the agreement of the nation and do carefully" (MAa)
Deformities, mutations
"It's possible to create a deformed child or mutant" (H)
"Danger to have some influence on descendant of those whose genes have been changed" (H)
"Deformity or genetic defect by mistake" (HA)
"Make deformed people (H), and deformed animals (A)"
"Strange animals may be made" (A)
"Can't control by human hand when mutation occurs" (PMA)
"Abnormalities which can't be predicted or found" (Aa)
"Abnormal propagation" (Pa)
"Afraid of unexpected mutation" (Ha)
"Deformity or violence by mutation" (HAa)
Human health effects, new human diseases, get cancer
"There is a danger to create a bad organism" (A,M)
"Possible to create something bad for human beings and animals" (M)
"It's possible to create a plant which has good characters but is noxious to humans" (P)
"It's possible to bring some disease like HIV" (M)
"It's quite possible to harm human beings, as well as ethical problems" (Ht)
"if it is misused new genetic diseases will be induced" (Ha)
"It will be more pathogenic and resistant to medicine" (Ma)
"New disease and new deformities" (Ha)
Humanity changed
"It is possible that a human which is different from ordinary is made" (H)
"Natural people will be lost" (H)
"Original humanity will be lost" (H)
"Will change the structure of the food industry and medical treatment" (Ma)
"Change of social standards cannot be predicted" (Ha)
"Culture will be destroyed" (Ha)
"Loss of human dignity" (Ha)
"Cultural chaos and destruction of the significance of human existence" (Ha)
Disaster, out of control, Dangerous
"Failure of manipulation brings worse characters or makes dangerous species" (All)
"What is done cannot be undone" (All)
"Scared of mistakes being made" (H)
"Worried about failure" (H)
"Researchers will make mistakes" (Alla)
"We cannot control in detail" (Alla)
"There must be an occasion of failure (accidentally or consciously) because it is done by humans and we don't know how much effect things have on human society or creatures, etc." (Alla)
"When we value this on commerce, we may end up destroying not only nature, but also human beings" (Alla)
Ecological and Environmental effects
"Unnatural animals may cause chaos in ecosystem" (A, + unnatural)
"It will bring about ecological destruction" (A)
"Destruction of ecology" (PMA)
"I don't have enough knowledge to point out where it's dangerous, but if the gene is operated endlessly I fell uneasy about what influence it has on ecology" (no response chosen, All)
"If a stronger species of plant or animal grows too much they will kill all the present species and destroy the current ecological balance" (All)
"Such animals will affect plant life and it will become like a desert" (A)
"Effect on natural development of plants (P) and animals (A)"
"Harm the ecosystem" (All)
"Dangerous to do with selfish understanding and analysis, need to do with balanced manipulation considering everything, including the ecosystem" (All)
"Unknown disease and ecosystem destroyed" (PMA)
"Danger for Japan leads to danger for all the earth. Need to stop pollution of earth and environment, and hope every life lives together" (All)
"It will be revenged unexpectedly by nature" (All)
"It may exterminate some plants (P), microbes (M), and animals (A)"
"Only the useful genes to humans will be left, loss of the natural gene pool" (Allt)
"Unpredictable bad variety will emerge and that will increase by natural selection" (All)
Biohazard, spread of genes, spread of harmful GMOs, New plant and animal disease
"Every technique has danger, for example, dangerous microbes might be made by mistake by inserting the wrong gene, and these may escape to the natural world" (All)
"There is a danger of leakage from enclosures because of the carelessness of some of the people" (All)
"Failure of experiment results in spread" (M)
"Microbes which are uncontrollable when spread to surroundings, but may be OK to do if we can handle them properly" (M)
"Possibility of new virus and insects being made" (PMA)
"Research always has mistakes, as a result have biohazard" (P)
"Not just for Japan, even if we have regulations biohazard always happens. It has the same face as nuclear reactors" (Allt)
"Abnormal gene may spread by improper management control" (PMAt)
"Make harmful breeds" (PAa)
"GMO may be released and spread" (PAa)
"I wonder whether the operation of pathogenic genes is safe it we can make microbes that live and propagate in oil" (Ma)
"Disturb the natural history of the natural world, and the poss