This file includes links to papers published by Eubios Ethics Institute, and some other organizations, in the first section. Next it includes topical extracts from EJAIB and EEIN between January 1994 - 2006 (older news items are in separate files). Last date of updating is referenced in the main News page. Latest news and papers is at the bottom of each of the two sections.
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Abbreviations for journals
Eubios Ethics Institute home page
New - searchable Abstracts on assisted reproduction from Ken Daniels
Japanese human cloning law (effective from May 2001)
Anees, M.Human Cloning: An Atlantean Odyssey? EJAIB 5 (1995), 36.
Editorial - Is bioethics about clones or relationships? - Darryl Macer EJAIB 7 (1997), 65-66.
Some ethical issues of cloning - Masahiro Morioka EJAIB 7 (1997), 67-8.
Commentary on Morioka - Munawar A. Anees EJAIB 7 (1997), 68.
The Successful Scottish Experiment on Cloning - A Great Event in Science - K. K. Verma and Rashmi Saxena EJAIB 7 (1997), 130.
Cloning Humans? The Chinese Debate and Why It Matters - Gerhold K. Becker EJAIB 7 (1997), 175-8.
Human Cloning - The Global Response - A.K. Tharien EJAIB 8 (1998), 9-10.
Israel Faces the Issue of Human Cloning: A Discussion of the Ethical and Social Implications - Yael Weiler EJAIB 8 (1998), 10-12.
Cloning and the New Ethic: Commentary on Yael Weiler - Frank J. Leavitt EJAIB 8 (1998), 12-3.
Human Cloning: Commentary on Tharien, Weiler, & Leavitt - Masahiro Morioka EJAIB 8 (1998), 13.
The Children Born from Human Cloning - Jean Kitahara-Frisch EJAIB 8 (1998), 83-4.
HUGO Ethics Committee - Statement on Cloning EJAIB 9 (1999), 70.
Cloning: Paradox, Paradigm and Ethics in Indian Society - Minakshi Bhardwaj & Jayapaul Azariah EJAIB 9 (1999), 71-3.
Legal and Ethical Aspects of Cloning - Jurgen Simon & Brigitte Jansen EJAIB 9 (1999), 98-99.
Human Cloning Legislation in Japan - Jiro Nudeshima > , EJAIB 11 (Jan 2001), 2.
Commentary on Nudeshima - Masahiro Morioka > , EJAIB 11 (Jan 2001), 2-3.
What is wrong about Human Reproductive Cloning? A Legal Perspective - Tade Matthias Spranger EJAIB 11 (July 2001), 101-102.
Legal Aspects of Human Cloning - A Reaction to Spranger - Verma EJAIB 12 (Jan. 2002), 30
Human Cloning : A Reaction to Verma - Tade Matthias Spranger EJAIB 12 (March 2002), 63.
German Parliament Paves the Way for ES Cell Research - Tade Matthias Spranger EJAIB 12 (March 2002), 63-64.
Cloning Bibliography updated March 1997
Human cloning in Singapore: Emergence of
Asian bioethics - Tade Matthias Spranger EJAIB 12 (July 2002), 122.
ES Cells and the definition of an embryo
- Richard M. Lebovitz EJAIB 12 (July 2002), 151-153.
EJAIB 13 (2003), 216-9 New Cloning Technologies and Bioethics Issues:
The Legislative Process in Korea - Sung-Goo Han,Young Je Yoo, & Wha-Joon Rho
EJAIB 14 (2004), 97-99 The ethical challenge of stem cell research and
tissue transplantation - Saeideh Ziaei and Mohsen Farokhi
Human Cloning & Embryonic Stem Cell Research: A View
from Theravada Buddhist Morality - Somparn Promta, EJAIB 14 (2004), 197-199.
The German Stem Cell Law: Contents and Criticism - Brigitte Jansen / JŸrgen Simon , EJAIB 14 (2004), 213-214.
Religion and opinion about reproductive human cloning - Joakim Hagelin , EJAIB 14 (2004), 214-216.
Luzitano B. Ferreira & ClŽa R. O. Ribeiro, Ethical issues about human reproductive cloningEJAIB 15 (March 2005), 63-7.
M.N.Jha, Cloning of Little 'Nikky': What Next? EJAIB 15 (May 2005), 90-92.
Karori Mbugua, Somatic Cell Nuclear Transfer: Some Ethical
Considerations
EJAIB 16 (May 2006), 78-85.
Karori Mbuegua, Stem Cell Research: Science, Ethics and the
Popular Media, EJAIB 17 (Jan. 2007), 5-10.
The reports from Washington of scientists who conducted experiments on embryo splitting has generated a range of opinions and comments. The European Parliament has unanimously adopted a resolution (B3-1519/93) to ban cloning. They say that any cloning for whatever purpose is "unethical, morally repugnant, contrary to respect for the person, and a grave violation of fundamental human rights which cannot under any circumstances be justified or accepted". They also note concern about eugenics and commercialisation of human genetics. They would like to call for a world conference to bring about an international agreement to ban the cloning of human beings. The resolution has a number of implications for bioethical debate, for example, why is the splitting of a human embryo (which happens in nature with twins) and the implantation of two embryos into a women to increase her chance of having a baby a violation of human rights?
It is apparent that we will see more discussion of this issue! A cover page article in Newsweek (8 Nov), 42-7, also looks at the topic, with a more mixed discussion. More comments are in BME 92 (Oct 1993), 1; (Nov), 2; Science 262 (1993), 652-3; New Scientist (30 Oct, 1993), 7. As I said in the last issue; EEIN 3: , this making of twins is not something so novel, and it is interesting to see all the attention. However, if it makes people think about these issues than that is good, but they should be more considered. If you want to see the abstract, it is number o-001 and a general prize paper in the abstracts in a November issue of Fertility & Sterility.
The UK has seen three topics come to broad press attention over the New Year, with much media attention. One is the issue of a black woman using a white egg donor; Times (1 Jan 1994), 1, 15; Washington Post (1 Jan 1994), A15, 24. This was claimed to be racial engineering, however, clinically it is indicated as no other donor is possible and the couple do not mind the colour. Another case was the birth of twins to a 59 year old English woman, given fertility treatment by Italian doctors. However, we should note that births of children to woman of this age do occur naturally, and were more common in the past. They are not to be generally recommended, or supported however. There is much less ethical support for the use of spare eggs from aborted fetuses, though it also needs discussion. In the UK Parliament it was called "womb robbing", Guardian (3 Jan 1994), 1, 16; Times (3 Jan), 1.
In the UK the Human Fertilisation and Embryology Act of 1990 states that embryos should not be stored frozen for more than 5 years, and the potential problems are discussed in Despatches 4(1), 8-9. In the UK there was also a recent case of an implantation of 9 embryos, Lancet 342 (1993), 1231; see also BMJ 307 (1993), 1281-2. On the risks of new approaches to IVF see New Scientist (27 Nov, 1993), 13-4.
Reviews of interest include: H.W. Jones & J.P. Toner, "The infertile couple", NEJM 329 (1993), 1710-5; C. Mastroyannis, "Gamete intrafallopian transfer: ethical considerations, historical development of the procedure, and comparison with other advanced reproductive technologies", F&S 60 (1994), 389-402. The difficulties and need for accurate record keeping and data on assisted reproductive technology are made in F&S 60 (1994), 403-5, 759-63. The possibility of increased ovarian cancer being associated with use of fertility drugs is raised in F&S 60 (1994), 406-8.
An extensive discussion of the secrecy/openness debate in donor insemination is in Politics & Life Sciences 12 (1993), 155-203. It includes papers by authors from New Zealand, Canada, Poland, U.K., France, USA, following a leading article, K.R. Daniels & K. Taylor, "Secrecy and openness in donor insemination", p. 155-70. It calls for governments to make donors lists more open, and that this would be to the advantage of everybody involves. The views that secrecy is best for some are not supported by the data. A recent study in New Zealand found that 51% of parents were definitely, and 32% probably, going to tell their child of their status. In France a study on the families that used artificial insemination has been stopped, BMJ 307 (1993), 1026. In the UK changes in the adoption law will make the opinions of the child more important, BMJ 307 (1993), 1231. The psychological similarity of adoption and IVF is discussed in book reviews in JAMA 270 (1993), 2383-4.
The technology for sperm separation is progressing, and success for sex selection in animals is steadily increasing, BMJ 307 (1993), 1303. Letters reporting fertilisation using testicular sperm are in Lancet 342 (1993), 1237-8. A new book on the technical side is S.J. Behrman et al., Progress in Infertility, 4th edition (640 pp., £110, Churchill Livingstone 1993).
A discussion of recent uses of reproductive technology and the ethical issues they raise is in Newsweek (17 Jan 1994), 38-43; Nature 367 (1994), 2, 99-100; Lancet 343 (1994), 165-6; SSM 38 (1994), v-viii. A discussion document from the UK HFEA, Donated Ovarian Tissue in Embryo Research and Assisted Conception is summarised in BME (Dec 93), 5; BMJ 308 (1994), 153. Comments are requested before 1 June, 1994. A discussion of "clones" is is in JAMA 271 (1994), 331-2. A general discussion of advances in technology is in Scientific American (Feb 1994), 13-5. Sex selection and UK law = is discussed inDispatches 4(2), 1-4.
The final report of the Canadian Royal Commission on New Reproductive Technologies, titled Proceed with Care, is available for sale. They recommend prohibition of techniques which are against "Canadian ethical and social values", and the establishment of a Commission to examine whether reproductive technologies are being performed in the public interest. They also look at genetic screening by preimplantation diagnosis and gene therapy, and use of fetal tissue. For a report see BMJ 308 (1994), 154.
A paper on the social counseling desirable for infertile couples is K. Daniels, "Infertility counselling: The need for a psychosocial perspective", Br. J. Social Work 23 (1993), 501-15. A paper on how to develop selection policies for use of assisted reproduction is in SSM 37 (1993), 1473-80. A study of what factors lead people to withdraw from a donor insemination program in New Zealand is reported in H.V. Danesh-Meyer et al., "Withdrawal from a donor insemination programme", Aust NZ J. Obstet. Gynaecol. 33 (1993), 187-90. The major reasons were natural conception, adoption or medical and social reasons.
A survey on the use of fertility drugs in the USA from 1973 - 1991 is in F&S 60 (1993), 1096-8. The effect of such drugs and in vitro methods on 106 triplet pregnancies is reported in F&S 60 (1993), 1031-4.
The UK Human Embryology and Fertilisation Act does permit the offering or preferential service to women who agree to donate eggs to other parents at the clinic, despite recent controversy about this; BME 95 (Feb 1994),6. However, the donor of gametes should only receive £15 plus reasonable expenses. Also on the ethical issues of sex selection see Galton Institute Newsletter (March 1994), 6-8.
The UK Parliament has passed a ban on the use of embryos from aborted fetuses being used in fertility treatments, Nature 368 (1994), 674-6; New Scientist (15 Jan 1994), 7. At first a committee and the HFEA had been asked to consider it, and was going to seek public opinion, BMJ 308 (1994), 153-4; Lancet 343 (1994), 165; but politicians decided to enact a law quickly, within 4 months of the controversy being raised (see earlier issues). The idea of politicians adding on issues to other bills, has upset many observers. The development of universal guidelines for experiments using eggs from aborted fetuses is called for in GEN (15 March 1994), 4, 22.
Another research result which may raise eyebrows is the success of growing sperm from germ cells in vitro, BMJ 308 (1994), 156; Cell 75 (1993), 997-1006... As discussed in the section above, the embryo research debate is also hot in the USA, with both the US and Canada deciding to slow down human reproduction research, Hospital Ethics (Jan), 10-12; BMJ 308 (1994), 154-5. The Swedish regulations are discussed in J. Assisted Reproduction & Genetics 10 (1993), 243-5.
A new book is Gwynne Basen, Margrit Eichler & Abby Lippman, eds., Misconceptions: The Social Construction of Choice and the New Reproductive and Genetic Technologies, (C$14.95, Voyageur Publishing, 82 Frontenac Street, Hull, Quebec J8X 1Z5, Canada; Toll free 1-800-268-2946). Any profits will go to the National Action Committee on the Status of Women in Canada to support their work for the women. Volume 2 is expected soon. The final report of the Canadian Royal Commission on New Reproductive Technologies, Proceed with Care, is available for C$52, or US$67.60 overseas, for two volumes.
A paper reporting attitudes is S.J. Genuis et al., "Public attitudes in Edmonton toward assisted reproductive technology", CMAJ 149 (1993), 153-61. The study found two thirds would donate an egg or sperm to a sibling, and 40% would donate to a stranger. 74% agreed with surrogacy for medical reasons, but 85% opposed it for convenience only. 72% thought that assisted reproductive technology should be regulated. Australian attitudes are reported in M.C. Bowman & D.M. Saunders, "Community attitudes to maternal age and pregnancy after assisted reproductive technology: too old at 50 years?", Human Reproduction 9 (1994), 167-71. 64% accepted oocyte donation (very similar to Canada, above), 55% accepted use of own gametes after menopause, and 38% accepted donated gametes being used after menopause. These suggest reasonable public support, which is interesting given the cases debated earlier in the year (see earlier issues) for older mothers, New Scientist (8 Jan 1994), 3, (15 Jan), 3. In France, the health minister has said fertility treatment should not be available to postmenopausal women, BMJ 308 (1994), 154; Lancet 343 (1994), 166. Italy has also said it will control their use, BMJ 308 (1994), 155.
Psychological aspects of donor insemination are discussed in J.R. Moreno et al., "Personality characteristics analysis in couples undergoing artificial insemination", Human Reproduction 9 (1994), 172-5. L.R. Schover et al., "Psychological screening and the success of donor insemination", Human Reproduction 9 (1994), 176-8. The ethical and social impact of reproductive technology is debated in Search 25: 53-6, 60-2; F&S 61 (1994), 236-8. A kit for DIY sperm testing will be on sale in the Netherlands soon, New Scientist (8 Jan 1994), 9. Book reviews of interest for reproductive technology are in Bioethics 8 (1994), 171-7.
An interesting figure is that in 1991 there were more than 13000 human embryos in frozen storage in Australia; Australian Doctor (4 Feb), 29. Many states do not impose a limit time on storage, though the 1993 Western Australian law puts a 3 year limit on storage and a maximum of three embryos at any time per couple; while South Australia is 10 years and Queensland 15 years.
The new French law on bioethics includes tough restrictions on embryo research, which will halt some research. IVF is limited to heterosexual couples of child-bearing age. It forbids mixing sperm. An exception for families with a history of genetic disease to use embryo biopsy was included however, Science 264 (1994), 1655; BMJ 308 (1994), 1186. Preimplantation diagnosis is discussed in Lancet 343 (1994), 972-3. The survival of a human embryo after two micromanipulations is reported in F&S 170: 1199-203. Also in France, a judge has ordered the destruction of two frozen embryos from a widow, BMJ 308 (1994), 1319-20. The case may be appealed, as it is strange that the embryos are not the property of the woman!
In the UK, the legal moves to ban egg implants from fetuses for infertility treatment are discussed in New Scientist (23 April 1994), 8; Nature 369 (1994), 598. Two reports from a group of Japanese scholars seeking legal regulations for assisted reproductive technology have been published (largely in Japanese - but English summary is available). Contact: Prof. Kunihiko Shoji, Faculty of Law, Hokkaido University, Kita-ku, kita 9, Nishi 6, Sapporo 060, JAPAN. The 1992 Brazilian general Medical Council's statement on death and artificial procreation is in IDHL 45: 100-2.
The question of the ethics of human cloning is debated is two papers, J.A. Robertson, "The question of human cloning", HCR 24(2): 6-14; R.A. McCormick, "Blastomere separation: some concerns", HCR 24(2): 14-6. Robertson argues it should be acceptable, as he sees no great risks from it. McCormack argues against it from the view of individuality being natural.
A discussion of ethical issues in post-menopausal pregnancy and birth is in IN/FIRE Ethics 3(1), 1-8; Monash Bioethics Review 13(2) (1994), 1-4. An editorial on oocyte donation to older women is in MJA 160 (1994), 244-5. Letters on age-related decline in fecundity are in F&S 170: 792-3. Another more general paper on the ethical issues of viewing the body as objects from a feminist outlook is R. Mykitiuk, "Fragmenting the body", Australian Feminist Law J. 2: 63-98. General letters on the infertile couple are in NEJM 330 (1994), 1154-5.
Papers on the counseling of couples receiving infertility treatment include K. Daniels & I. Stjerna, "Infertility: The Social Work Contribution", Socionomen 6 (1993), 41-6; K. Daniels, "Adoption and Donor Insemination: factors influencing couples' choices", Child Welfare LXXIII: 5-14. In a New Zealand study of insemination it was found that most couples had considered adoption. However, this may depend on the country, for example in Japan adoption is less common than in the West. An interesting topic. In a major long-term US study of adopted children released in June, it was found that parents of adopted children are less likely to divorce, and no negative factors were found in the children. A related book review is JAMA 271 (1994), 1212. Children of single parent families may be most affected by socioeconomic factors than parent number, BMJ 308 (1994), 114-5. Let us hope economic conditions are getting better, as in 1992 in the UK one out of three babies were born to unmarried women (31%; compared to 14% in 1982).
The Vatican has condemned artificial insemination of lesbians, following an Italian doctors report (Reuter News, 24 June). A review of the book, John Boswell, Same-Sex Unions in Premodern Europe, (Villard Books, 412pp., US$25), is in Newsweek (20 June), 47. He has studied the evidence that homosexual marriages have long been performed, and had church blessing in Medieval times.
A study of the techniques claimed to separate sperm by sex chromosome finds that they do not work as claimed; F&S 61 (1994), 720-6; New Scientist (4 June 1994), 8. The crystal structure of human chorionic gonadotropin is reported in Nature 369 (1994), 455+.
A third Indian state has banned the use of amniocentesis to chose fetal sex, now Rajasthan, Maharashtra and Gujurat ban the use; Reproductive Freedom News (10 June 1994), 8. The proposed national law has been held up for 3 years in Parliament.
There has been a claim at the annual meeting of the American College of Neuropsychopharmacology that estrogen given to postmenopausal women increases their thinking ability and memory, to add to the current data suggesting benefits from osteoporosis and cardiopulmonary disease; Japan Times (2 July 1994), 12. The use of thyroid hormone and estrogen, and positive effects on bone density are discussed in JAMA 271 (1994), 1245-9, 1283-4. Also on estrogen, JAMA 271 (1994), 1670-1.
Sex selection and preimplantation diagnosis is discussed in F&S 72 (1999), 595+. A study of IVF in Sweden 1982-1995 found multiple births were the main cause of adverse outcomes, Lancet 354 (1999), 1572-3, 1579-85. It recommends two embryos in each transfer. The risk of cancer after use of fertility drugs is discussed in Lancet 354 (1999), 1573, 1586-90. The science of male infertility is discussed in JAMA 282 (1999), 1414; Lancet 354 (1999), 1713-8; F&S 72 (1999), 702-6. A study finding intrauterine delivery of frozen sperm is of higher success rate is F&S 72 (1999), 792-5. Birth of a baby from round spermatids isolated from frozen testicular tissue is reported in F&S 72 (1999), 539-41; and on extraction of sperm from frozen tissues, F&S 72 (1999), 785-91. Sperm freezing survival may be species specific, F&S 72 (1999), 747-8. Extending in vitro embryo growth to 5-6 days may improve IVF success rates, F&S 72 (1999), 418-22. The question why we are limiting choices for infertile couples? Is asked in CMAJ 161 (1999), 1411-2; Pinheiro, RC. Et al. "Effectiveness of in vitro fertilization with intracytoplasmic sperm injection for severe male infertility", CMAJ 161 (1999), 1397-1401.On difficulties in reversing menopause, NS (2 Oct. 1999), 3, 5.A paper on the impact of cloning is Solter, D. "Cloning and embryonic stem cells: Anew era in human biology and medicine", Croatian Medical J, 40 (1999), 309-18; and on laws, Hsu, MB. "Banning human cloning: An acceptable limit to scientific inquiry or an unconstitutional restriction of symbolic speech", Georgetown Law J. 87 (1999), 2399-430. Also on cloning, Nature Genetics 23 (1999), 395. In Japan researchers who fused nuclei of human cells with bovine egg cells in cancer research have broken rules designed to stop human cloning, Lancet 354 (1999), 1801. Japan may outlaw human reproductive cloning, Lancet 354 (1999), 1885; BMJ 319 (1999), 1390.
France may be lifting its ban on human embryo experiments, following the recommendation of the Conseil d'Etat, Nature 402 (1999), 563, 565. The NIH has set rules that allow funding of some embryonic stem cell research, Science 286 (1999), 2050-1; BMJ 319 (1999), 1517. Rat spinal cord function has been restored in experiments using stem cells, Science 286 (1999), 1826-7. Also on stem cells, Science 286 (1999), 2238-9; BMJ 319 (1999), 1308.
The case of three identical boys, triplets has been reported in Spain, Lancet 354 (1999), 1882. Multiple pregnancies are discussed in F&S 72 (1999), 970-2; JAMA 282 (1999), 1832-8. The possibility that humans will no longer procreate by sex is discussed in Time (8 Nov. 1999), 46-9; MJA 171 (1999), 659, 660-4; NS (25 Dec. 1999), 54-5. The possibility that sex surveys to survey behaviour actually shape our behaviour is discussed in Christchurch Star (29 Dec. 1999), B1; The Independent (Dec. 1999). There is some concern in the UK on where to limit the use of preimplantation diagnosis, BME 152 (1999), 5-6. Some parents use it to help sick siblings by providing a tissue matching embryo (and child), NS (11 Dec. 1999), 18-9. On the use of IVF, Plomer, AL. Et al. "Rationing policies on access to in vitro fertilization in the National Health Service, UK", Reproductive Health Matters 7 (1999), 60-70; Waller, L. "The costs of treating infertility", J. Law & Med. 7 (1999), 183-90.
The Donor Conception Support Group of Australia Inc is a self-funding organization run by volunteers that has been in existence since 1993. Starting with a membership of 20 adults, we have now grown to approximately 600 adults and 300 children with members in the USA, Canada, Hong Kong, New Zealand, Sweden, U.K. ,Germany and Indonesia. The membership is made up of people considering or using donor sperm, egg or embryo, those who already have children conceived on donor programmes, adult donor offspring and donors. We also have Social Workers, Doctors, clinic staff as members of the group. Their Aims Are 1) To provide support to People considering or currently on donor sperm, egg or embryo programs, donors and recipient families- parents and most importantly the children themselves. 2) To increase public awareness of the use of donor gametes. To contact the DCSG the address is Donor Conception Support Group of Australia Inc, P.O.Box 53, Georges Hall 2198, NSW Australia.
A report from Ron's angels and buying eggs is Newsweek (8 Nov. 1999), 54-5; and on the future prospects, Nature 402 (1999), 585. The psychological profile of oocyte donors is reported in F&S 72 (1999), 1066-72. Two papers on surrogacy and law are in Medical Law Review 7 (1999), 1-20, 38-57. The protection of liberty is discussed in Daar, JF. "Assisted reproductive technologies and the pregnancy process: Developing an equality model to protect reproductive liberties", AJLM 25 (1999), 455-78. Reproduction after death is discussed in Bennett, B. "Posthumous reproduction and the meanings of autonomy", Melbourne University Law Review 23 (1999), 286-307. DALYs are applied to reproductive health in Reproductive Health Matters 7 (1999), 118-29. ART is discussed in Roberts JH. "Coalition building and public opinion: new reproductive technologies and Canadian society", Intl J of Technology Assessment in Health Care 15 (1999), 15-21.
There have been some recent cases of sex determination cases in India being investigated by the Medical Council, Lancet 354 (1999), 1981. A philosophical defense is Savulescu, J. "Sex selection: the case for", MJA 171 (1999), 373-5. A study on three sex prediction methods, fetal heart rate test, the Chinese calendar test and the Draino test, is Ostler, S. & Sun, A. "Fetal sex determination: the predictive value of 3 common myths", CMAJ 162 (2000), 1525-6.
Safety is reviewed in Loft A. et al. "A Danish national cohort of 730 infants born after intracytoplasmic sperm injection (ICSI) 1994-1997." Human Reproduction14 (1999): 2143-8. Letters on male infertility and the risk of diseases in future generations are Lancet 354 (1999), 1906-8. IVF pregnancies may have increased early rate of pregnancy loss, F&S 72 (1999), 1061-5. The question of whether there are marker loci for fertility is discussed in F&S 72 (1999), 1148-50. In general on the science, Science 286 (1999), 2265; F&S 72 (1999), 1035-40; BMJ 319 (1999), 1388; MJA 171 (1999), 342-3, 353-7.
Human rights and transexualism is discussed in Health & Human Rights 4 (1999), 134-64. Transexualism is discussed in Lancet 354 (1999), 1828-9. Social factors can make gay men suicidal, Science News 156 (1999), 261.
Part of the US National Commission on Bioethics report on ethical issues in stem cell research is included in BME 153 (1999), 8-10. Researchers can use human stem cells with strict guidelines, JAMA 283 (2000), 325. Japan will allow stem cell research, Nature 403 (2000), 470; NatBio 18 (2000), 246. University of Wisconsin has announced it will distribute ES cell lines, Science 287 (2000), 948-9. A discussion of some of the issues is Annas, GJ. Et al. "Stem cell politics, ethics and medical progress", NatMed. 6 (2000), 1339-41. A call for therapeutic cloning research to progress is NS (29 Jan. 2000), 3. A review is Fiddler, M. et al. "The role of preimplantation geneticist in human cloning", Prenatal Diagnosis 19 (1999), 1200-4.
Cloning of monkeys is reported in Chan, AWS. Et al. "Clonal propagation of primate offspring by embryo splitting", Science 287 (2000), 317-8. It may be possible to regenerate fertile mice, Ogawa, T. et al. "Transplantation of male germ line stem cells has restored fertility in infertile mice", NatMed. 6 (2000), 29-34; 16-7; Lancet 355 (2000), 205. Nuclear transfer into mouse zygotes is reported in Nature Genetics 24 (2000), 108-9. Some animals may be unclonable, NS (5 Feb. 2000), 4; Nature Genetics 24 (2000), 109. A reliable, noninvasive technique for spindle imaging and enucleation of mammalian oocytes is described in NatBio 18 (2000), 223-5.
An Internet site offering parents choice for DNA tests and estimating the costs of the testing is www.genochoice.com. A general comment on IVF and the Internet is Politics & Life Sciences 18 (1999), 119-22. Papers on ethics and ART are in Otago Bioethics Report 9 (No.1 Feb. 2000), 1, 8-20. The UK has allowed frozen eggs to be used for fertility treatment, Lancet 355 (2000), 387; BMJ 320 (2000), 334. A report on a New York State Task Force on Life and the Law, F&S 73 (2000), 21-23. A UK report, Royal College of Obstetricians and Gynaecologists, The Management of Infertility in Tertiary Care (2000) has recommended a maximum of 2 embryos be implanted at one time, BMJ 320 (2000), 271. A study suggesting transfer at 5 days rather than 3 days is the same is F&S 73 (2000), 117-22. A UK case where a woman is suing that she can use her stored eggs is Lancet 355 (2000), 50.
The Ethics Committee of the Japan Obstetrics and Gynecology committee made a decision against allowing preimplantation diagnosis for a family who had one child with muscular dystrophy who requested sex selection to avoid the birth of a further child with muscular dystrophy, Asahi Shinbun (27 Feb. 2000), 3. The argument given was that there was still a risk of a child, suggesting if the gene probe was used it would be OK. There have been other cases approved in Japan.
A review is Fidler, AT. & Bernstein, J. "Infertility: From a personal to a public health problem", Public Health Reports 114 (1999), 494-511. A report on a case in the UK where Nottingham University has sued a former employee for foreign earnings is BMJ 320 (2000), 268. On the cost effectiveness of treatment for infertility, and interuterine insemination versus IVF, Lancet 355 (2000), 2, 13-8. During fertilization a sperm's mitochondria are labeled with ubiquitin for destruction, Science News 157 (2000), 5. The failure to do this results in abnormal embryos, Lancet 355 (2000), 200.
;A series of papers on the ethical and scientific issues of stem cell research are in Science 287 (2000), 1397, 1417-46; NatMed. 6 (2000), 231. Patient voices are a powerful voice in promoting research. A book review on human cloning is SSM 50 (2000), 1167-8. Scientists are urged to be careful, Young, FE. "A time for restraint", Science 287 (2000), 1424. European views on the ethics are discussed in Lenoir, N. "Europe confronts the embryonic stem cell research challenge", Science 287 (2000), 1425-6. Stem cells may be useful against brain cancer, NS (15 April 2000), 5. Also see the section on Organ Transplants. A discussion of the protein that may determine if a cell will be a stem cell is NS (8 April 2000), 4; Nature Genetics 24 (2000), 372-6. A review of cells for tissue engineering is TIBTECH 18 (2000), 17-9; and for research, Thomson, JA. & Odorico, JS. gHuman embryonic stem cell and embryonic germ cell linesh, TIBTECH 18 (2000), 53-7.
;Japan introduced a bill to make a 5 year ban on human cloning, but to still allow stem cell research, Nature 404 (2000), 321; NatMed. 6 (2000), 239. However it did not have majority support in the Parliament so may not proceed, UK ethicists supported stem cell research, Nature 404 (2000), 697.
;A review is Garrison, M. "The technological family: What's new and what's not", Family Law Quarterly 33 (1999), 691-704. A paper on the questions faced by children born from ART is Woodward, S. "Whose child am I anyway?", Cambridge Alumini Magazine 29 (Lent Term 2000), 26-9. The gathering of sperm from the dead is discussed in Strong, C. "Ethical and legal aspects of sperm retrieval after death or persistent vegetative state", JLME 27 (Winter 1999), 347-58; plus pp. 359-65. Ethics of ovarian transplants are discussed in F&S 73 (2000), 443-6. A survey of embryo donation in the USA found it more often contemplated than performed, F&S 73 (2000), 215-20. Discussion of use of ICSI by a person with HIV is in HCR 30 (Jan. 2000), 23-5. Viagra can also help women conceive, NS (8 April 2000), 6.
;Results of the survey of Japanese IVF clinics has found that 40% implanted 4 or more embryos, and some clinics routinely use fetal reduction to overcome the problem of multiple pregnancies, Mainichi Newspaper (3 May 2000), 3, 23. Letters on limiting multiple births are in Lancet 355 (2000), 1103-4. The German Chamber of Physicians has called for a relaxation on the rules that govern preimplantation diagnosis, Nature 404 (2000), 118. The Swiss population turned down a referendum that would have outlawed IVF by 75%, Nature 404 (2000), 221. In general on ethics and law of ART, F&S 73 (2000), 447-52.
;A call for more research into the effects of IVF in the UK has been made, BMJ 320 (2000), 960. Letters on a Swedish IVF, Lancet 355 (2000), 844-7. Commercial surrogacy is being debated again in the UK, Brinsden, PR et al. "Treatment by in vitro fertilization with surrogacy: experience of one British centre", BMJ 320 (2000), 924-8, 928-9. The Italian Medical Association is challenging a court ruling that permitted a surrogate pregnancy to be overseen by a doctor, Lancet 355 (2000), 996. Sperm donors in the Netherlands will remain anonymous for a further two years, Lancet 355 (2000), 1249. Israel is investigating claims of illegal ova sales, Lancet 355 (2000), 633. The results of a Canadian and Japanese study of the role of fathers is SSM 50 (2000), 1257-72. A study on the increased mortality risk for lone mothers is Lancet 355 (2000), 1203, 1215-9.
;An Australian sued a London IVF clinic alleging that they used his sperm without permission, BMJ 320 (2000), 464. The case has been settled. The dispute in Nottingham over IVF services has come to discussion of reimbursement of medical service fees, Lancet 355 (2000), 817. A US physician was fired over an embryo mixup, Nature 404 (2000), 326.
;Poor oocyte quality is an indication for ICSI, F&S 73 (2000), 465-9. Use of frozen sperm allows better timing for ICSI, F&S 73 (2000), 453-8. On male infertility, F&S 73 (2000), 435-42.
The ethics of reproductive and therapeutic cloning is discussed in Monash Bioethics Review 19 (2000), 33-44; JME 26 (2000), 166-70, 222; BME 156 (2000),11. On the stem cell funding debate in the USA, Nature 405 (2000), 1, 6; Science 288 (2000), 1442; NatMed. 6 (2000), 614; GeneWatch 13 (April 2000), 4-5. Celera and Geron Corp. are combining research on genes involved in differentiation, Nature 405 (2000), 726. A call to make the number of implanted embryos flexible is BMJ 320 (2000), 1672. Ovarian function from stored and transplanted tissue is reported in NEJM 342 (2000), 1919.
Debate on preimplantation diagnosis is continuing in Germany, Lancet 355 (2000), 1980. Israel may supervise fertility treatments more but also liberalize oocyte donations, Lancet 355 (2000), 1979; and there has been a case reported of oocyte selling in Israel, BMJ 320 (2000), 1425. On giving or selling gametes, Daniels, KR. "To give or sell human gametes \ the interplay between pragmatics, policy and ethics", JME 26 (2000), 206-11; Parker, M. "Public deliberation and private choice in genetics and reproduction", JME 26 (2000), 160-65. A new method for preserving eggs by incubating them in mice is expected, NS (1 July 2000), 7. The question of whether paternal mtDNA can be inherited depends on recombination between mtDNA from the sperm and mtDNA in the oocyte, Lancet 355 (2000), 1290-1. Ethics of surrogacy is discussed in KEIJ 10 (2000), 39-58. A paper in general is Nelson, JL. "Reproductive ethics and the family", New Zealand Bioethics J. 1 (2000), 4-10; pp. 11-8 commentaries; Agard, ES. & Wallach, EE. "The limits of reproductive technology: Who decides?", J. Clinical Ethics 10 (2000), 329-32. The ethics of ART for persons with HIV is discussed in NEJM 342 (2000), 1748-50. A report from the French Bioethics Committee on medicalisatiuon de la sexualite is Cahiers 23 (2000), 21-6. Sildenafil to improve erectile dysfunction is discussed in BMJ 320 (2000), 1156-7, 1165. A book review of Dreger, AD. Intersex in the Age of Ethics (Hagerstown Univ. Pub. 1999) is NEJM 342 (2000), 1457. The UK has announced it will allow embryo cloning (Observer, 30 July 2000). A paper on cloning in Italian is Itinerarium 8 (2000), 73-8. Reviews include Nature 406 (2000), 361-4; Edwards, BE. Et al. "The human pluripotent stem cell: impact on medicine and society", F&S 74 (2000), 1-7; NatBio 18 (2000), 827-8. The third volume from the US NBAC Ethical Issues in Human Stem Cell Research has been published, on religious perspectives (June 2000). A paper against cloning is Kass, LR. "The wisdom of repugnance", The New Republic (2 June 1997), 17-26. Papers in Chinese on human cloning are in Chinese Bioethics Newsletter 3 (Spring 1998), 1-4. Humans can grow hepatocytes from bone marrow stem cells, Nature 406 (2000), 257; Lancet 356 (2000), 48. Diabetes research is helping fund stem cell research, Nature 406 (2000), 224. European ethicists have been discussing ES cell research, but in some countries like Sweden research on embryos until 14 days age is already permitted, NatMed. 6 (2000), 845. On the fate of frozen embryos, NEJM 343 (2000), 373-6. A study on the psychological status of IVF patients during pregnancy is reported from USA in F&S 74 (2000), 1159-64. On the success of IVF, Lancet 356 (2000), 257-8. IVF can be preferable to fertility drugs, BMJ 321 (2000), 134; F&S 74 (2000), 8-9. Obstetric interventions among private and public patients are discussed in BMJ 321 (2000), 125-6; and insurance, F&S 73 (2000), 1267-8; Am. J.O&G. 182 (2000), 891-5. Social benefits from oocyte donation and shared embryos include higher overall success rate, F&S 74 (2000), 1165-9. Issues for lesbian families in management of donor insemination are discussed in Sociology Health & Illness 22 (2000), 477-99. Pregnancy rates depend on the provider at embryo transfer, F&S 74 (2000), 80-6. Higher rate of pregnancy comes from first time transfers and more embryos, Am. J.O&G. 182 (2000), 1001-4. However more embryos leads to multiple births, JAMA 284 (2000), 299-300; but gonadotropins may reduce the risk of higher order multiple pregnancy, NEJM 343 (2000), 2-7, 58-9. In the USA black women have poorer outcomes from IVF programs, F&S 73 (2000), 1170-3. The Internet is being used by many couples to seek advice, from all economic levels, F&S 74 (2000), 1179-82. Mutations in an oocyte-derived growth factor gene cause infertility, NatGen. 25 (2000), 279-83; NS (July 2000), 16. On the consequences of infertility for the offspring, The Economist (10 June 2000), 95-6. UK will allow research on embryonic stem cells, NatBio 18 (2000), 1034; NS (19 Aug. 2000), 3; NatMed. 6 (2000), 950; Lancet 356 (2000), 693; BMJ 321 (2000), 527; Nature 406 (2000), 813, 815; 407 (2000), 559; and the NIH offers guidelines for stem cell research amid broader debate, NatBio 18 (2000), 1035; NS (19 Aug. 2000), 4-5, 14-5; (2 Sept. 2000], 6; Science 289 (2000), 1269-70, 1442-3, 1469, 1877-8; JAMA 284 (2000), 1773-4; Nature 406 (2000), 925. The US NIH will fund human stem cell research, BMJ 321 (2000), 527. The Netherlands may impose a 3 year ban on cloning of human embryos for research, BMJ 321 (2000), 852. The Holy See has made a statement, Pontificia Academia Pro Vita, Declaration on the Production and Scientific and Therapeutic Use of Human Embryonic Stem Cells, (25 August 2000, 18pp.) which calls on the use of adult stem cells instead. The Nuffield Council on Bioethics published a discussion paper in April 2000. A Spanish comment on research into totipotent stem cells is Eidon 5 (Oct 2000), 1-7. Different countries use the progress in other countries to call for liberalization of research policies on stem cells, Bioethics Examiner 4 (Fall 2000), 1, 4; BME 160 (2000), 9-11. On the option of adult stem cells, Bioethics Research Notes 12 (2000), 25-6; NS (19 Aug. 2000), 16. Also on the pros and cons of stem cell research, JAMA 284 (2000), 681-2. Bioengineering with stem cells is reported in Lancet 356 (2000), 1500 (see also Organ Transplants section). Flk1-positive cells from ES cells can serve as vascular progenitors, Nature 408 (2000), 92-6. Also on stem cell development, Nature 407 (2000), 750-4. The US company Clonaid has said it has US$500,000 from a couple who wants it to clone their dead child, Science 289 (2000), 2271. Europeans asked British members of Parliament to reject allowing cloning by nuclear transfer, NatMed. 6 (2000), 1068; Nature 407 (2000), 122. The possibility of using nuclear transfer to make a male egg, and then fertilization after that, will allow gay couples to have their own genetically related children, Times (25 Sept. 2000), 1, 4. There was controversy in Japan over the use of a fathers-in-law sperm to fertilize a womanfs egg, which is against the guidelines of the Japan Society of Obstetrics & Gynecology, NS (Sept. 2000), 5. Changes in the UK Human and Fertilization and Embryology Act include permission for the fatherfs name to appear in a birth certificate when his sperm were used after his death, Lancet 356 (2000), 840. There is a test case of a legal demand for details of genetic fathers, BMJ 321 (2000), 654. Also on donor insemination, Daniels, K. gDonor insemination New Zealand: from Early Beginnings to the Millenniumh, Pathways (NZ Infertility Society) (Summer 1999), 6-9; F&S 74 (2000), 607-8; Kalfoglou, AL. & Geller, G. gA follow-up study with oocyte donors exploring their experiences, knowledge, and attitudes about the use of their oocytes and the outcome of the donationh, F&S 74 (2000), 660-7. Screening gametes for CF status is discussed in MJA 173 (2000), 380-1. A letter on infertility As a symptom not a disease is F&S 74 (2000), 398. A US Ethics Committee Report on financial incentives for oocyte donors is in F&S 74 (2000), 216-20. The 1997 results of ART in the USA found an increase in success rate to 40% delivery per transfer, and a total of 25,000 babies born, F&S 74 (2000), 641-53. Chromosome analysis might improve the success rate, Lancet 356 (2000), 1497. A discussion of the Netherlands policy to give IVF for unmarried women is Lancet 356 (2000), 1512-3. In Australian the issue of discrimination against unmarried couples is being debated, Lancet 356 (2000), 746. An Italian women is attempting to give birth to octuplets that were conceived after fertility treatment, Sunday Times (17 Sept. 2000), 21. It may be good to give advice to couples to use contraception before IVF down-regulation, F&S 74 (2000), 655-9. On risks of multiple births, F&S 74 (2000), 617-23. On the psychological issues, Daniels, K. gThe psychology of assisted reproduction \ or Psychology assisting its reproduction? A responseh, Australian Psychologist 34 (1999), 211-5; Daneisl, K. gA biopsychosocial perspectiveh, Orgyn 3 (2000), 11-14. On ovarian transplantation, F&S 74 (2000),423-4. The relationship of embryo cryopreservation to cost effectiveness of ART is discussed in F&S 74 (2000), 613-4. However then the issue is disposition of extra embryos, F&S 74 (2000), 213-5. Blastocyst culture increases efficiency of oocyte donation, F&S 74 (2000), 482-6. Male sperm mobility is dictated by motherfs mtDNA, AJHG 67 (2000), 543-8. The question of whether storing cord blood cells is a private matter is discussed in Lancet 356 (2000), 1417. The use of immunologic tests is discussed in F&S 74 (2000), 439-41. A possible link between testicular cancer and infertility is discussed in BMJ 321 (2000), 781-2, 789-92. A study on sex selection is Cohen, A. gExcess female mortality in India: The case of Himchal Pradeshh, AJPH 90 (2000), 1369-71. In Japan there is the reverse trend, a decline in laes, Lancet 356 (2000), 738-9. The sex ratio in Austrian chloracne cohort is discussed in Lancet 356 (2000), 1271-2. The UK Parliament has authorised the use of stem cells and embryos for medical research, Nature 409 (2001), 5; Lancet 356 (2000), 2162; BMJ 321 (2000), 1427-8; Lancet 356 (2000), 1825. France and Italy are authorizing the use of somatic cell nuclear transfer for human embryo research, Nature 408 (2000), 629. On the debate on the use of ES cells, NS (18 Nov. 2000), 10-2; (16 Dec. 2000), 20; NatMed. 6 (2000), 1303; Nature 408 (2000), 773, 897-8; PNAS 97 (2000), 13473-5; Science 290 (2000), 1672-4. Papers on the ethics include: Lanza, RP. Et al. “The ethical validity of using nuclear transfer in human transplantation”, JAMA 284 (2000), 3175-9; Juengst, E. & Fossel, M. “The ethics of embryonic stem cells – Now and forever, cells without end”, JAMA 284 (2000), 3180-3, 3175 Ethics Committee of the American Society for Reproductive Medicine, “Human somatic cell nuclear transfer (cloning)”, F&S 74 (2000), 873-6; Nature 408 (2000), 275, 277. The US position has been changed to negative, Nature 408 (2000), 887-8. There are differences in the sources of ES cells for each application, Nature 408 (2000), 513; The Scientist (27 Nov. 2000), 20-4. The Greek origin of the word cloning is discussed in Nature 408 (2000), 905.
In
Japan HIV positive men have been offered use of IVF
to have children without HIV, Nature408 (2000), 633. Doctors at
Tottori University Hospital in Yonago, Tottori Prefecture, have conducted in
vitro fertilization with sperm taken from an HIV-positive man using, for the
fifth time, a technique that reduces the risk of infecting the wife and unborn
baby to almost zero (Japan Times 9
Jan., 2001).
The future of IVF may
have no limits, Lancet Perspectives356 (2000), s52; NS(11 Nov. 2000), 20; (2 Dec. 2000), 40-5. On IVF in Italian, Itinerarium 8 (Sept. 2000), 109-24. Access for gay
and lesbian couples is discussed in GeneWatch 14 (Jan. 2001), 8-9.
Further on the UK positive support for stem cell research, Lancet 356 (2000), 329-30; BMJ 322 (2001), 7, 189; Science 291 (2001), 23. An international group of scientists has announced a cloning clinic in the USA, BMJ 322 (2001), 315; Science 291 (2 Feb. 2001). As reported in EJAIB 11 (2001), 2; the Japanese law on cloning bans implantation for pregnancy but allows research, Science 291 (2001), 1872-3. The situation in the USA is unclear, NS (20 Jan. 2001), 17. In general on cloning, NatGen 27 (2001), 15
The media has reported several claims of cloned human babies being born, but these babies are awaiting a chance for scientists to verify they are really clones. The announcements have led to renewed efforts to ban cloning in the USA, Nature 421 (2003), 3; NS (21 Dec., 2002), 21; Science 297 (2002), 1951. California has passed a law allowing stem cell research from embryos and those made by nuclear transplant, HCR 32 (Nov. 2002), 7. Jeremy Rifkin has warned scientists that he will sue them if they make mice-human chimeras, Nature 421 (2003), 4; see also, Nature 420 (2002), 255. Sources of adult stem cells are discussed in The Scientist (16 Sept. 2002), 30; Nature 420 (2002), 734-5; NatGen 32 (2002), 557-8; SA (June 2002), 16-7 There have been efforts for greater international cooperation to research stem cells, Nature 421 (2003), 102. Stem cells can still be attacked from the immune system, Science 297 (2002), 175-7. In general on stem cell research, Science 297 (2002), 923-5; 298 (2002), 37-8; Nature 418 (2002), 903; 419 (2002), 583-5; NatGen 32 (2002), 90-1; Lancet 360 (2002), 1226; Current Biology 12 (2002), R705-6.
Australia voted to allow research to make stem cells on spare embryos, Nature 420 (2002), 599; on background see Nature 419 (2002), 4; NS (21 Sept., 2002), 9; NatMed. 8 (2002), 430. Discussion of stem cell policy is in NatGen 32 (2002), 567; NEJM 347 (2002), 1576-82, 1619-22; Lancet 360 (2002), 1080; Gene Therapy 9 (2002), 674-8; Science 297 (2002), 1477. The views of the Catholic church are discussed in JME 28 (2002), 228; Lancet 359 (2002), 2036-7. The UN is split over the convention to ban human cloning, Science 298 (2002), 1316; NS (28 Sept., 2002), 11; Lancet 360 (2002), 1574. In the USA still most private labs are not regulated for ART, Nature 420 (2002), 1. Korea has tightened its law after claims of cloning, Nature 419 (2002), 424. India has stopped exports of embryos, Nature 419 (2002), 238. On stem cells in East Asia, Nature 419 (2002), 334-6; and Saudi Arabia, Science 296 (2002), 2331. Maturation of mouse germ cells in vitro is reported in Nature 418 (2002), 497.
Discussion of the claims of human cloning by Raelians is in BME 184 (Jan. 2003), 5; Science 299 (2003), 343-4; Associated Press (30 Jan. 2003); NS (11 Jan., 2003), 3, 8-11; Economist (4 Jan. 2003), 61-2. There is a dilemma for journals about publishing results of human cloning experiments, Nature 421 (2003), 199. US scientific panels and politics are discussed in NatMed. 9 (2003), 153. On cloning debates, see the journal Cloning. A two year process to gain approval for research on stem cells in Germany is reported in Science 299 (2003), 31. There can be different interpretations of the same results about the promise of stem cell research, Science 299 (2003), 324. On stem cell research, Bioethics 16(Nov. 2002), special issue; NatMed. 9 (2003), 156-7; Nature 421 (2003), 102; Science 299 (2003), 1009. Attempts to stop research on human-animal chimeras have been made in the USA by legal means of patent protection, Nature 421 (2003), 4. The US House of representatives passed a law banning all types of cloning, Science 299 (2003), 799. Discussion
of the ethics of stem cell and cloning research is in Alpha Omega
V (No. 3, 2002), 391-6; Nature 422
(2003), 654; SA (April 2003), 21; Bioethics 16 (2002), 493-567; Lancet 361 (2003), 1354. Asian nations may be close to a consensus on cloning, NatMed. 9 (2003), 248. The outcome from a 1999 Korean
consensus conference on cloning are in Developing World Bioethics 2 (2002), 159+. On Indian guidelines, APBN 7 (2003), 49. Sweden is allowing therapeutic cloning,
Research Europe (6 Feb. 2003), 7.
The US House of representatives passed an anitcloning law but the Senate is not
expected to approve it, SCRIP 2830
(7 March 2003), 18. On the Californian ES cell law, NatBio 20 (2002), 1073. The US bioethics council was split
on cloning, NatBio 20 (2002), 765.
Stem cell research debates include TIBTECH 21 (2003), 109-13; Nature
422 (2003), 787; Science 299
(2003), 1509, 1661, 1830-1; NS (26
April 2003), 17; BMJ 326 (2003),
838.
Human embryo research is discussed in Um, Y-R. "South Korea: Human embryo research", CQHE 12 (2003), 268-78; National Catholic Bioethics Quarterly 3 (2003), 111-38; NatBio 21 (2003), 482-3. A paper on use of embryos is Fitzpatrick, W. "Surplus embryos, nonreproductive cloning, and the intend/forsee distinction", HCR 33 (May 2003), 29-36.
A nursing perspective on cloning is in Nursing Ethics 10 (2003), 238-54. Three articles on cloning in Italian are in Itinerarium 11 (2003), No. 24; pp. 71-106. Interspecies hybrids between rabbits and humans have been used to make stem cells in China, and there is controversy about the plan, Nature 424 (2003), 711: NS (23 Aug. 2003), 14. Reasons for making chimeric embryos are discussed in NS (12 July 2003), 3. On ethics of cloning, Nature 424 (2003), 14; SA (July 2003), 24-5. The diversity of views on use of ES cells in Europe is discussed in Science 301 (2003), 289, 1017. Laws and ES cells are discussed in NEJM 349 (2003), 300. The AMA has approved ES cell research, BMJ 326 (2003), 1417. Alan Trounson has resigned as director of the Australian stem cell centre, Nature 424 (2003), 716. A cautious note on stem cell research with comparisons to gene therapy is NS (19 July 2003), 24; see a conference report from BIO2003 in NS (5 July 2003), 19.
Ethics of ICSI are discussed in Cahiers (CCNE, France) 35 (April 2003), 15-23. The UN has delayed a vote on human cloning. European allies and dozens of Islamic states that support therapeutic cloning blocked consideration of the cloning ban at the United Nations until the end of 2005 (http://www.washingtonpost.com/wp-dyn/articles/A8840-2003Nov6.html) There was scientific lobbying on both sides, Current Biology 13 (2003), R785-6. A technique to combine 2-3 cloned embryos into one increases the chance of making a live animal, NS (18 Oct. 2003), 19. Even if they do not want to clone babies, researchers must to learn how to produce duplicate human cells safely. That is the conclusion of experts who have outlined a program to identify and solve the problems that currently plague cloning (http://www.newscientist.com/news/news.jsp?id=ns99994334) The law over somatic cell nuclear transfer is not keeping up with technology, NatBio 21 (2003), 969-70. The UK has licensed Roslin Institute to create embryos for research, JAMA 290 (2003), 449-50. On ethics of ES cell research, Law and the Human Genome Review 18 (2003), 43-54; Catholic Medical Quarterly 54 (2003), 8-11. A critical analysis of ES cell research in Australia is in J. Law & Medicine 10 (2003), 514-30. Scientists in China have used interspecies hybrids of rabbi and human to make ES cells, NS (23 Aug. 2003), 14. On ES cells, NEJM 349 (2003), 267-74, 275-86, 1480-2; Science 301 (2003), 1017; 302 (2003), 371; PNAS 100 (2003), 11817-926; Nature 425 (2003), 778-9; Cell 113 (2003), 551-7; Current Biology 13 (2003), R375-6. Visiting German professors who work on ES cells might face jail upon return, Science 301 (2003), 577. The ethics of cloning are discussed in Bioethics 17 (2003), 447-59, 503-525; CQHE 12 (2003), 353-410. The issue of consent for use of spare embryos and stem cell research is discussed in Health Law Review 11 (3, 2003), 3-12; Science 301 (2003), 927. The UN has left the debate on human cloning on hold, ready to resume later in the year, HCR 34 (Jan. 2004), 5-6; Current Biology 13 (2003), R937-9. Those who have comments on this should send to the editor who is working on a report for United NatioNS University on the issues for consideration when the UN General Assembly revisits the issue. On ethics and cloning stem cells, Monash Bioethics Review 22 (Jan. 2003), 8-24; New Zealand Bioethics J. 5 (2004), 22-8, 29-30; JME 29 (2003), 207; Sociology of Health & Illness 25 (2003), 793-814; Nature 426 (2003), 603; 428 (2004), 587; NS (21 Feb. 2004), 3. A paper in Italian on cloning ethics is in Bioetica e Cultura 12 (No. 2, 2003), 283-8. Against reproductive cloning, NS (22 Nov. 2003), 23; (24 Jan. 2004), 4; BMJ 328 (2004), 185; Lancet 363 (2004), 827-8. The use of pluripotent adult germ cells in treatment is discussed in Ford, NM. "Using pluripotent germ cells in regenerative medicine. An ethical alternative", National Catholic Bioethics Quarterly 3 (2003), 697-706.There was controversy over the departure of two members of the US President's Bioethics Council who were positive towards stem cell research, Science 303 (2004), 1447. Harvard University is setting up a privately funded US$100 million institute for stem cell research, Science 303 (2004), 1453; Nature 428 (2004), 8. Stem cell research might be a ballot issue in California, Science 303 (2004), 293; NS (20 March 2004), 7. New Jersey also has backed use of stem cells, NatBio 22 (2004), 142.
European Parliament members approved the funding of stem cell research using human embryos, in countries that do not outlaw it, BMJ 327 (2003), 1248. On EU regulation of stem cell research, JME 29 (2003), 203-8; NatBio 22 (2004), 157-8. Spain will support stem cell research, Nature 428 (2004), 247. On policy in China, Nature 427 (2004), 278.
Researchers in Korea have published results of making human ES cells from a cloned human embryo, Woo Suk Hwang et al., "Evidence of a pluripotent human embryonic stem cell line derived from a cloned blastocyst", Science 303 (2004), 1669-74, 937-9, 1581; Nature 427 (2004), 664; NatBio 22 (2004), 361; JAMA 291 (2004), 1185-6. This type of experiment could be legally performed in some countries but not in others. More ES cell lines are needed, NEJM 350 (2004), 1275-6, 1351-2; NatBio 22 (2004), 159-63, 399-400. On the potential for stem cell therapy, NatBio 22 (2004), 283-5; NS (21 Feb. 2004), 6-7, 16-7; BMJ 328 (2004), 484; Lancet 363 (2004), 581. Making stem cells is discussed in Nature 426 (2003), 490-1. Embryonic germ cells and male gametes can be made from ES cell lines in mice, Nature 427 (2004), 106-7, 148-54.
ES stem cell research is debated in Law and the Human Genome Review 19 (July 2003), 91-108. A review paper on the ethics is Walters, L., "Human embryonic stem cell research: An intercultural perspective", KIEJ 14 (2004), 3-38; see also, pp. 55-114; HCR 34 (March 2004), 49; SSM 58 (2004), 401-9; Nature 429 (2004), 1. The ethical guidelines for HESC research from Shanghai are in KIEJ 14 (2004), 47-54. UN politics and cloning is discussed in NatMed. 12 (2003), 1437; Current Biology 13 (2003), R937-9; NS (21 Feb. 2004), 16-7. A paper on the ethics of transplanting human stem cells into nonhuman embryos is NatMed. 10 (2004), 331-5.
Despite accusatioNS of unethical behaviour the Korean scientists who made the first cloned human ES cells defend their work, Science 304 (2004), 945; Nature 429 (2004), 3, 12-4; and more on the discovery, Lancet 363 (2004), 623; NatBio 22 (2004), 361; BMJ 328 (2004), 415-6, 421; and another report, NEJM 350 (2004), 1353-5. On US stem cell politics, Science 304 (2004), 820; NatBio 22 (2004), 509-10; NatMed. 10 (2004), 317; Current Biology 13 (2004), R253-4; Nature 428 (2004), 4, 587; NEJM 350 (2004), 1275-6, 1351-2. Private funding is expected to fill in the gap left from the absence of US federal funds, JAMA 291 (2004), 2059-60; NatMed. 10 (2004), 320. Brazil may pass a law to ban therapeutic cloning, Lancet 363 (2004), 1125. On Canadian regulation, Lancet 363 (2004), 955; Chinese, Nature 427 (2004), 278; and in Europe, NatMed. 12 (2003), 1440.
Use of stem cells in diabetes is discussed in Nature 429 (2004), 30-1. In general on stem cell research, Economist (3 Jan. 2004), 53-5; NatMed. 10 (2004), 23, 224-5; Nature 428 (2004), 607-9. The implicatioNS of parthenogenesis in mice for humaNS is discussed in NS (24 April 2004), 5. A possible human chimera is reported in Prenatal Diagnosis 23 (2003), 935-7.
A
Christian ethics debate on cloning is in Science & Christian Belief 16 (2004), 45-55. Discussion of cloning ethics in
Italian is in Bioetica e Cultura
XIII (2004), 23-44. On the US political views on stem cell research, Science 304 (2004), 1088; BMJ 328 (2004), 1094. Discussion of the ethics of the Korean
cloning results and experiments are in Nature 428 (2004), 490; Newsweek
(1 March 2004), 44-5; Science 304
(2004), 945.
A
review of stem cell research is SA (June
2004), 3, 60-7. The genes that control human ES cell growth and differentiation
are identified in NatBio 22
(2004), 707-16. The UK has decided to spend a further US$30 million for stem
cell research, Nature 428 (2004),
495. The UK has opened a public repository for stem cells, Nature 428 (2004), 333; Science 304 (2004), 1239. Nancy Reagan endorses human stem
cell research, Nature 428 (2004),
116. Male germline stem cells have been regenerated by spermatogonial
dedifferentiatiation in vivo, Science 304 (2004), 1331-4.
The UK has approved the licensing of their first trial for nuclear transfer therapeutic
cloning involving use of spare eggs
from an infertility centre in Newcastle, BMJ 329 (2004), 417; NS (21 Aug. 2004), 8-9; Science 305 (2004), 1102; Nature 430 (2004), 817. The UK is funding more research, Current
Biology 14 (2004), R493, R592-3. The
Bioethics committee of the Council for Science and Technology Policy, and the
Ministry of Health Ethics Committee have approved plans to allow therapeutic
cloning research in Japan, but the
guidelines may take another year to develop, Nature 430 (2004), 5; NatMed. 10 (2004), 763; Science 304 (2004), 1729; NatBio 22 (2004), 937. Mexico has reversed a ban on stem
cell research, NatMed. 10 (2004),
656. France has banned reproductive and therapeutic cloning, BMJ 329 (2004), 130. Arab states may also be preparing to
ban cloning, Lancet 363 (2004),
2061. A discussion of California
Proposition 71 that will be on the election ballot in November in the USA to
promote therapeutic cloning research is Science 305 (2004), 1544-5; Nature 430 (2004), 125. There may be a US repository for
stem cells, Nature 429 (2004),
691, 430 (2004), 389. On the US debates, Science 305 (2004), 760; NS (29 May 2004), 49; JAMA 292 (2004), 163. The lobbying of scientists supported
by the Genetics Policy Institute and others to the UN to allow therapeutic cloning research is discussed in
Lancet 363 (2004), 1962; NatGen 36 (2004), 781.
Papers on cloning bans in Italian are
in Bioetica e Cultura 13 (2004,
No. 1), 23-66. Laws against reproductive
cloning are discussed in J. Law & Medicine 11 (Feb. 2004), 351-72. Problems of stem cell
research are reviewed in National Catholic Bioethics Quarterly 4 (2004), 289-302. On 2 September, 2004, Singapore banned reproductive cloning but permitted therapeutic
cloning, Nature 431 (2004), 119. Canada has banned human reproductive cloning, HCR 34 (May 2004), 5. Australian debates on human ES cell research are reviewed in Health
Law Review 12 (No.2, 2004), 27-33.
Child welfare and human cloning is discussed in Keough, W. "All in the
family: A child welfare perspective on human reproductive cloning", Health
law Journal 11 (2003), 71-88. Also on ethics of stem cell research, Science 305 (2004), 1402; JAMA 292 (2004), 791-2; BMJ 329 (2004), 466.
Comments on the ethics of the creation
of the human ES cell line in Korea
are in Science 305 (2004), 944-5.
The Korean Ministry of health & Welfare has funded Catholic University of
Korea medical school US$12 million for research into use of adult stem cells,
Zenit.org, 18 June 2004. In general on stem cell research prospects, Science 305 (2004), 27, 929; TIBTECH 22 (2004), 155-6; NS (19 June 2004), 12; NatBio 22 (2004), 804-5, 863-6; JAMA 292 (2004), 75, 81, 104-5. Derivation of midbrain
dopamine neurons from human ES cells is reported in PNAS 101 (2004), 12543-8.
There has been criticism of an alleged "pre-mature" paper on adult
stem cells published in an on-line physics journal, Nature 429 (2004), 590; Applied Physics A (doi:10.1007/s00339-004-2816-6; 2004). Stem cell
research will extend to space with NASA, NS (21 Aug. 2004), 4. There is discussion of a claim
that Panos Zavos had made cloned embryos from dead humans and cow eggs, Nature 431 (2004), 118.